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    Gtf2a2 general transcription factor 2A subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83828, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gtf2a2provided by RGD
    Official Full Name
    general transcription factor 2A subunit 2provided by RGD
    Primary source
    RGD:620720
    See related
    Ensembl:ENSRNOG00000056701 AllianceGenome:RGD:620720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TBP-class protein binding activity; and protein dimerization activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of transcription factor TFIIA complex and transcription factor TFIID complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 354.3), Muscle (RPKM 304.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2a2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79542682..79556484)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70662447..70675576)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76422341..76435587)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094198 Neighboring gene BCL2 interacting protein 2 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene selenoprotein K, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The concept of compensation in cognitive aging: the case of prose processing in adulthood. Dixon RA, et al. Int J Aging Hum Dev, 1992-1993. PMID 1302244
    2. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. Ozer J, et al. Genes Dev, 1994 Oct 1. PMID 7958899
    3. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. Ozer J, et al. J Biol Chem, 1996 May 10. PMID 8626665
    4. Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. Sun X, et al. Genes Dev, 1994 Oct 1. PMID 7958900
    5. Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. DeJong J, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724559, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188808

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor IIA subunit 2
    Names
    TFIIA-gamma
    general transcription factor IIA subunit 2
    general transcription factor IIa 2
    general transcription factor IIa, 2 (12kD subunit)
    general transcription factor2A subunit 2
    transcription initiation factor IIA gamma chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412186.1 → NP_001399115.1  transcription initiation factor IIA subunit 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O08950
      UniProtKB/TrEMBL
      A6KEU8, A6KEU9
      Related
      ENSRNOP00000068825.1, ENSRNOT00000085496.2

    2. NM_053345.2 → NP_445797.1  transcription initiation factor IIA subunit 2

      See identical proteins and their annotated locations for NP_445797.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O08950
      UniProtKB/TrEMBL
      A6KEU8, A6KEU9
      Related
      ENSRNOP00000071778.2, ENSRNOT00000084148.2
      Conserved Domains (1) summary
      COG5123
      Location:3 → 103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

    RNA

    1. NR_178067.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      79542682..79556484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266219.1 → XP_063122289.1  transcription initiation factor IIA subunit 2 isoform X1

    2. XM_063266221.1 → XP_063122291.1  transcription initiation factor IIA subunit 2 isoform X3

      UniProtKB/TrEMBL
      A6KEV1, B5DEM4

    3. XM_063266222.1 → XP_063122292.1  transcription initiation factor IIA subunit 2 isoform X3

      UniProtKB/TrEMBL
      A6KEV1, B5DEM4

    4. XM_063266220.1 → XP_063122290.1  transcription initiation factor IIA subunit 2 isoform X1

    5. XM_039082206.2 → XP_038938134.1  transcription initiation factor IIA subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      O08950
      UniProtKB/TrEMBL
      A6KEU8, A6KEU9
      Conserved Domains (1) summary
      COG5123
      Location:3 → 103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08950.1 GenPept UniProtKB/Swiss-Prot:O08950

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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