Tprn taperin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tprnprovided by RGD
Official Full Name: taperinprovided by RGD
Primary source: RGD:1562935
See related: Ensembl:ENSRNOG00000010896 AllianceGenome:RGD:1562935
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatase binding activity. Predicted to be involved in auditory receptor cell stereocilium organization; sensory perception of sound; and stereocilium maintenance. Predicted to be located in stereocilium. Predicted to be active in stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 79. Orthologous to human TPRN (taperin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 146.9), Kidney (RPKM 95.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28474322..28481800)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8076164..8083642)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2480232..2487710)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell stereocilium organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
involved_in stereocilium maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in stereocilium maintenance	ISO Inferred from Sequence Orthology more info
involved_in stereocilium maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in stereocilium base	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium base	ISO Inferred from Sequence Orthology more info
located_in stereocilium base	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: taperin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024309.2 → NP_001019480.2 taperin

See identical proteins and their annotated locations for NP_001019480.2

Status: VALIDATED

Source sequence(s)

BC083928, JAXUCZ010000003

UniProtKB/Swiss-Prot

Q5XHX2

Related

ENSRNOP00000014489.4, ENSRNOT00000014489.6

Conserved Domains (3) summary

PHA03247
Location:103 → 461

PHA03247; large tegument protein UL36; Provisional

pfam13914
Location:507 → 645

Phostensin; Phostensin PP1-binding and SH3-binding region

pfam13916
Location:8 → 89

Phostensin_N; PP1-regulatory protein, Phostensin N-terminal