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    Man1b1 mannosidase, alpha, class 1B, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499751, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Man1b1provided by RGD
    Official Full Name
    mannosidase, alpha, class 1B, member 1provided by RGD
    Primary source
    RGD:1563595
    See related
    Ensembl:ENSRNOG00000012559 AllianceGenome:RGD:1563595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ERMan1; RGD1563595
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and trimming of terminal mannose on B branch. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 195.1), Adrenal (RPKM 189.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Man1b1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28539778..28563155)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8143877..8165007)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2547259..2569051)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene dipeptidylpeptidase 7 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In vitro mannose trimming property of human ER α-1,2 mannosidase I. Aikawa J, et al. Glycoconj J, 2012 Jan. PMID 22160784
    2. Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Avezov E, et al. Mol Biol Cell, 2008 Jan. PMID 18003979, Free PMC Article
    3. The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported. Herscovics A, et al. Glycobiology, 2002 Apr. PMID 12090241
    4. Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis. Tremblay LO, et al. Glycobiology, 1999 Oct. PMID 10521544
    5. Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41. Sevilla LM, et al. J Immunol, 2004 Aug 15. PMID 15294975

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum quality control compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
    Names
    ER alpha-1,2-mannosidase
    ER mannosidase 1
    NP_001102666.1
    XP_038961587.1
    XP_038961588.1
    XP_063140410.1
    XP_063140411.1
    XP_063140412.1
    XP_063140413.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109196.1 → NP_001102666.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

      See identical proteins and their annotated locations for NP_001102666.1

      Status: VALIDATED

      Source sequence(s)
      BC166449
      UniProtKB/Swiss-Prot
      B2GUY0
      UniProtKB/TrEMBL
      A0A8L2Q8I6, A6JT43
      Related
      ENSRNOP00000016846.6, ENSRNOT00000016846.6
      Conserved Domains (1) summary
      pfam01532
      Location:214 → 653
      Glyco_hydro_47; Glycosyl hydrolase family 47

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28539778..28563155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284340.1 → XP_063140410.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A224

    2. XM_063284343.1 → XP_063140413.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X3

    3. XM_063284341.1 → XP_063140411.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

    4. XM_039105659.2 → XP_038961587.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

      Conserved Domains (1) summary
      pfam01532
      Location:76 → 515
      Glyco_hydro_47; Glycosyl hydrolase family 47

    5. XM_063284342.1 → XP_063140412.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

    6. XM_039105660.2 → XP_038961588.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X4

      Conserved Domains (1) summary
      pfam01532
      Location:1 → 333
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GUY0.2 GenPept UniProtKB/Swiss-Prot:B2GUY0

    Gene LinkOut

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