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    Tnfaip8l1 tumor necrosis factor, alpha-induced protein 8-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 66443, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tnfaip8l1provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 8-like 1provided by MGI
    Primary source
    MGI:MGI:1913693
    See related
    Ensembl:ENSMUSG00000044469 AllianceGenome:MGI:1913693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIPE1; 2600017J23Rik
    Summary
    Predicted to enable identical protein binding activity. Involved in negative regulation of TOR signaling. Located in cytoplasm. Orthologous to human TNFAIP8L1 (TNF alpha induced protein 8 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 8.7), thymus adult (RPKM 7.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfaip8l1 in Genome Data Viewer
    Location:
    17 29.19 cM; 17 D
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56469439..56491249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56162439..56184249)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene leucine-rich alpha-2-glycoprotein 1 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene STARR-positive B cell enhancer ABC_E5621 Neighboring gene STARR-positive B cell enhancer ABC_E7547 Neighboring gene myeloid derived growth factor Neighboring gene dipeptidylpeptidase 9 Neighboring gene RIKEN cDNA A230051N06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy. Zhang X, et al. FEBS J, 2023 Feb. PMID 36111440
    2. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Zhang Z, et al. Oncogene, 2015 May 14. PMID 25043299
    3. The expression of TIPE1 in murine tissues and human cell lines. Cui J, et al. Mol Immunol, 2011 Jul. PMID 21600655
    4. TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. Wu H, et al. Hepatology, 2021 Sep. PMID 33713358
    5. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. Liu L, et al. Redox Biol, 2022 Apr. PMID 35152003, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation.
      Title: Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation.
    2. TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
      Title: TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
    3. TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
      Title: TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
    4. TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
      Title: TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
    5. TIPE1(TNFAIP8-like 1)protein was detected in a variety of tissues such as neurons, brain, hepatocytes, germ cells of female and male reproductive organs, muscular tissues and cells of epithelial origin it was not expressed in mature T or B lymphocytes
      Title: The expression of TIPE1 in murine tissues and human cell lines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TOR signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 1
    Names
    TNF alpha-induced protein 8-like protein 1
    TNFAIP8-like protein 1
    oxidative stress regulated gene-beta
    oxy-beta
    tumor necrosis factor, alpha-induced protein 8-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025566.3 → NP_079842.2  tumor necrosis factor alpha-induced protein 8-like protein 1

      See identical proteins and their annotated locations for NP_079842.2

      Status: VALIDATED

      Source sequence(s)
      AK136962, BY733616
      Consensus CDS
      CCDS28897.1
      UniProtKB/Swiss-Prot
      Q3U6E5, Q8K288, Q9D0N6, Q9DBH7
      Related
      ENSMUSP00000076961.7, ENSMUST00000077788.7
      Conserved Domains (1) summary
      pfam05527
      Location:25 → 177
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56469439..56491249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160743.1 → XP_036016636.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U6E5, Q8K288, Q9D0N6, Q9DBH7
      Conserved Domains (1) summary
      pfam05527
      Location:25 → 177
      DUF758; Domain of unknown function (DUF758)

    2. XM_030249985.1 → XP_030105845.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U6E5, Q8K288, Q9D0N6, Q9DBH7
      Conserved Domains (1) summary
      pfam05527
      Location:25 → 177
      DUF758; Domain of unknown function (DUF758)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K288.1 GenPept UniProtKB/Swiss-Prot:Q8K288

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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