Acacb acetyl-Coenzyme A carboxylase beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acacbprovided by MGI
Official Full Name: acetyl-Coenzyme A carboxylase betaprovided by MGI
Primary source: MGI:MGI:2140940
See related: Ensembl:ENSMUSG00000042010 AllianceGenome:MGI:2140940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acc2; Accb
Summary: Enables acetyl-CoA carboxylase activity. Involved in several processes, including energy homeostasis; malonyl-CoA biosynthetic process; and negative regulation of fatty acid beta-oxidation. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in axial skeleton; cranium; and liver. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 37.5), heart adult (RPKM 32.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 F

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114284748..114388822)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114146321..114250761)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
Title: WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
Using mice with Ser(79)Ala/Ser(212)Ala knock-in mutations (ACC DKI) the authors find that inhibition of ACC phosphorylation leads to reduced appetite in response to fasting or cold exposure.
Title: AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.
AMPK-ACC signaling is coupled to the control of thrombosis by specifically modulating thromboxane and granule release in response to collagen.
Title: AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.
Findings suggest that ACC2 deletion leads to intramyocellular lipid reduction without suppressing glucose use via an elevation in acetyl-CoA metabolism even under high-fat diet conditions and offer new mechanistic insight into the therapeutic potential of ACC2 inhibition on insulin resistance.
Title: ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice.
Lipogenesis is dispensable for liver tumorigenesis in mice treated with diethylnitrosamine, and ACC enzymes have an important role in redox regulation and cell survival.
Title: Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
of ACCs decreased polyunsaturated fatty acid (PUFA) concentrations in liver due to reduced malonyl-CoA, which is required for elongation of essential fatty acids.
Title: Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
The excess of ACCbeta might contribute to exacerbation of podocyte injury in the kidney of an animal model for diabetes mellitus, and the AMPK/ACCbeta pathway may be a novel therapeutic target for the prevention of diabetes-related podocyte injury.
Title: Overexpression of acetyl CoA carboxylase β exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice.
PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2.
Title: PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
These results suggest that ACC2 is dispensable for CD8+ T cell responses.
Title: Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.
AMPK-dependent inactivation of ACC is not essential for the control of myocardial FAO and subsequent cardiac function during a variety of conditions involving AMPK-independent and AMPK-dependent metabolic adaptations.
Title: AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI597064 (e-PCR)
- UniSTS:179238

Acacb (e-PCR), detects polymorphism
- UniSTS:527230

Acacb (e-PCR), detects polymorphism
- UniSTS:516498

AW743042 (e-PCR)
- UniSTS:207851

C87246 (e-PCR)
- UniSTS:207853

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetyl-CoA carboxylase activity	ISO Inferred from Sequence Orthology more info
enables biotin binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in glucose import	ISO Inferred from Sequence Orthology more info
involved_in intracellular aspartate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular glutamate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lactic acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malonyl-CoA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetyl-CoA carboxylase 2

Names: ACC-beta

NP_001390456.1

EC 6.4.1.2

NP_001390457.1

EC 6.4.1.2

NP_001390458.1

EC 6.4.1.2

NP_598665.2

EC 6.4.1.2

XP_006530175.1

EC 6.4.1.2

XP_006530177.1

EC 6.4.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403527.1 → NP_001390456.1 acetyl-CoA carboxylase 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC122282
NM_001403528.1 → NP_001390457.1 acetyl-CoA carboxylase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC122282

Related

ENSMUST00000143276.2
NM_001403529.1 → NP_001390458.1 acetyl-CoA carboxylase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC122282
NM_133904.3 → NP_598665.2 acetyl-CoA carboxylase 2 isoform 2

See identical proteins and their annotated locations for NP_598665.2

Status: VALIDATED

Source sequence(s)

AC122282

Consensus CDS

CCDS19561.1

UniProtKB/Swiss-Prot

E9Q4Z2, Q6JIZ0

Related

ENSMUSP00000099642.2, ENSMUST00000102582.8

Conserved Domains (4) summary

COG0439
Location:250 → 753

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00364
Location:887 → 951

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1770 → 2324

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:952 → 1678

ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

114284748..114388822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530112.4 → XP_006530175.1 acetyl-CoA carboxylase 2 isoform X1

See identical proteins and their annotated locations for XP_006530175.1

Conserved Domains (4) summary

COG0439
Location:250 → 753

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00364
Location:887 → 951

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1791 → 2345

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:952 → 1699

ACC_central; Acetyl-CoA carboxylase, central region
XM_006530114.5 → XP_006530177.1 acetyl-CoA carboxylase 2 isoform X3

Conserved Domains (4) summary

COG0439
Location:58 → 561

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00364
Location:695 → 759

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1599 → 2153

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:760 → 1507

ACC_central; Acetyl-CoA carboxylase, central region