Resp18 regulated endocrine-specific protein 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Resp18provided by RGD
Official Full Name: regulated endocrine-specific protein 18provided by RGD
Primary source: RGD:3555
See related: Ensembl:ENSRNOG00000019704 AllianceGenome:RGD:3555
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to act upstream of or within in utero embryonic development. Located in perikaryon; rough endoplasmic reticulum lumen; and secretory granule. Used to study hypertension and renal fibrosis. Orthologous to human RESP18 (regulated endocrine specific protein 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 351.9), Testes (RPKM 336.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84213844..84220186, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76765179..76771824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82470794..82477136, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18.
Title: Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18.
Findings suggest regulated endocrine-specific protein-18 ( Resp18) as a gene associated with the development of hypertension and renal disease.
Title: Targeted disruption of regulated endocrine-specific protein ( Resp18) in Dahl SS/Mcw rats aggravates salt-induced hypertension and renal injury.
Resp18 gene expression varies with activation of the corpus ghrelin-secreting cells and the antral gastrin-secreting cells.
Title: Regulated endocrine-specific protein 18 (RESP18) is localized to and regulated in A-like cells and G-cells in rat stomach.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulated endocrine-specific protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019278.1 → NP_062151.1 regulated endocrine-specific protein 18 precursor

See identical proteins and their annotated locations for NP_062151.1

Status: PROVISIONAL

Source sequence(s)

L25633

UniProtKB/Swiss-Prot

P47940

UniProtKB/TrEMBL

A0A0G2JZD6, A6JW14

Conserved Domains (1) summary

pfam14948
Location:37 → 113

RESP18; RESP18 domain