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    CG4267 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33405, updated on 10-May-2024

    Summary

    Official Symbol
    CG4267provided by FlyBase
    Primary source
    FLYBASE:FBgn0264979
    Locus tag
    Dmel_CG4267
    See related
    AllianceGenome:FB:FBgn0264979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31686; Dmel\CG4267; Dmel_CG4267
    Old locus tag
    Dmel_CG31686
    Summary
    Predicted to enable lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in embryonic large intestine and organism. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H); LIPI (lipase I); and PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Genomic context

    See CG4267 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2242378..2245274)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2242378..2245274)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Testis EndoG-Like 2 Neighboring gene Testis EndoG-Like 1 Neighboring gene long non-coding RNA:CR42859 Neighboring gene Serine protease 12 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables triglyceride lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG4267-PA
    CG4267-PB
    NP_001259919.1
    NP_608661.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2242378..2245274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272990.1NP_001259919.1  uncharacterized protein Dmel_CG4267, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ96
      Conserved Domains (2) summary
      cd00707
      Location:71347
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:64351
      Lipase; Lipase
    2. NM_134817.3NP_608661.1  uncharacterized protein Dmel_CG4267, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ96
      Related
      FBpp0077431
      Conserved Domains (2) summary
      cd00707
      Location:71347
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:64351
      Lipase; Lipase