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    ND-B17.2 NADH dehydrogenase (ubiquinone) B17.2 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33443, updated on 10-May-2024

    Summary

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    Official Symbol
    ND-B17.2provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B17.2 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031436
    Locus tag
    Dmel_CG3214
    See related
    AllianceGenome:FB:FBgn0031436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey62; B17.2; BcDNA:GH12382; CG3214; Dmel\CG3214; dNDUFA12; N7BM; NDUFA12; Q9VQD7
    Summary
    Predicted to be involved in mitochondrial ATP synthesis coupled electron transport and response to oxidative stress. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ND-B17.2 in Genome Data Viewer
    Location:
    23A1-23A1; 2-7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2579201..2580172, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2579201..2580172, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene insensitive Neighboring gene Early boundary activity 2 Neighboring gene Actin-related protein 2/3 complex, subunit 5 Neighboring gene Dynamin related protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. White PM, et al. Genetics, 2017 Apr. PMID 28159754, Free PMC Article
    2. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
    3. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. Yin S, et al. PLoS One, 2013. PMID 24069262, Free PMC Article
    4. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
    5. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial ATP synthesis coupled electron transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B17.2 subunit
    Names
    CG3214-PA
    CG3214-PB
    CG3214-PC
    FBpp0077425
    NADH ubiquinone oxidoreductase B17.2
    NADH-ubiquinone oxidoreductase subunit B17.2
    NADH:ubiquinone oxidoreductase B17.2 subunit
    ND-B17.2-PA
    ND-B17.2-PB
    ND-B17.2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2579201..2580172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144298.2 → NP_001137770.1  NADH dehydrogenase (ubiquinone) B17.2 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSI7, Q9VQD7
      Conserved Domains (1) summary
      pfam05071
      Location:40 → 135
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

    2. NM_001273015.1 → NP_001259944.1  NADH dehydrogenase (ubiquinone) B17.2 subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSI7, Q9VQD7
      Conserved Domains (1) summary
      pfam05071
      Location:40 → 135
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

    3. NM_134848.3 → NP_608692.1  NADH dehydrogenase (ubiquinone) B17.2 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSI7, Q9VQD7
      Related
      FBpp0077425
      Conserved Domains (1) summary
      pfam05071
      Location:40 → 135
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSI7 Q8MSI7
    Q9VQD7 Q9VQD7

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