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    Tspo Translocator protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33231, updated on 10-May-2024

    Summary

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    Official Symbol
    Tspoprovided by FlyBase
    Official Full Name
    Translocator proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031263
    Locus tag
    Dmel_CG2789
    See related
    AllianceGenome:FB:FBgn0031263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey116; CG2789; Dmel\CG2789; dTSPO; tspo
    Summary
    Involved in determination of adult lifespan; positive regulation of apoptotic process; and regulation of oxidative phosphorylation. Located in mitochondrial outer membrane. Is expressed in adult head and organism. Orthologous to several human genes including TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Tspo in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (559612..560523)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (559612..560523)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor beta3 Neighboring gene Signal peptide peptidase Neighboring gene Ets at 21C Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene uncharacterized protein Neighboring gene Notchless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. Lin R, et al. Aging Cell, 2014 Jun. PMID 24977274, Free PMC Article
    2. TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila. Lin R, et al. PLoS Genet, 2015 Aug. PMID 26241038, Free PMC Article
    3. Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila. Cho JH, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25979357
    4. An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia. Lee E, et al. Curr Biol, 2008 Dec 23. PMID 19097904, Free PMC Article
    5. A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine. Russi M, et al. Hum Mol Genet, 2020 Oct 10. PMID 32744307

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial TSPO function plays an important role in ethanol sensitivity and tolerance.
      Title: TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translocator protein
    Names
    CG2789-PA
    Tspo-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      559612..560523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134687.4 → NP_608531.1  translocator protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPR1
      Related
      FBpp0077726
      Conserved Domains (1) summary
      pfam03073
      Location:17 → 161
      TspO_MBR; TspO/MBR family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPR1 Q9VPR1

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