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    ATPsynD ATP synthase, subunit D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42291, updated on 10-May-2024

    Summary

    Official Symbol
    ATPsynDprovided by FlyBase
    Official Full Name
    ATP synthase, subunit Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016120
    Locus tag
    Dmel_CG6030
    See related
    AllianceGenome:FB:FBgn0016120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATP syn-d; ATPQ; ATPsyn-d; ATPsyn-D; ATPsyn-delta; CG6030; Dmel\CG6030
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval muscle system; extended germ band embryo; spermatozoon; and visceral muscle primordium. Orthologous to human ATP5PD (ATP synthase peripheral stalk subunit d). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See ATPsynD in Genome Data Viewer
    Location:
    91F1-91F1; 3-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19095000..19096271)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14920722..14921993)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46041 Neighboring gene center divider Neighboring gene mitochondrial ribosomal protein L55 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12a5

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton motive force-driven ATP synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP synthase, subunit D
    Names
    ATP synthase D chain
    ATP synthase chain D
    ATP synthase subunits d
    ATP synthase, subunit d
    ATP synthase,d
    ATPase synthase, subunit d
    ATPsyn-d
    ATPsynD-PA
    ATPsynD-PB
    ATPsynD-PC
    CG6030-PA
    CG6030-PB
    CG6030-PC
    F0/F1 ATP synthase D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19095000..19096271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300472.1NP_001287401.1  ATP synthase, subunit D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V344, Q24251, Q2XYL2, Q8MTU3, Q9VE03
      UniProtKB/TrEMBL
      A0A0B4LHL7
      Conserved Domains (1) summary
      pfam05873
      Location:11160
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    2. NM_169847.3NP_732400.1  ATP synthase, subunit D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V344, Q24251, Q2XYL2, Q8MTU3, Q9VE03
      UniProtKB/TrEMBL
      A0A0B4LHL7
      Related
      FBpp0083141
      Conserved Domains (1) summary
      pfam05873
      Location:11160
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    3. NM_079678.6NP_524402.1  ATP synthase, subunit D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V344, Q24251, Q2XYL2, Q8MTU3, Q9VE03
      UniProtKB/TrEMBL
      A0A0B4LHL7
      Related
      FBpp0083142
      Conserved Domains (1) summary
      pfam05873
      Location:11160
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)