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    GatA Glutamyl-tRNA amidotransferase, subunit A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42283, updated on 10-May-2024

    Summary

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    Official Symbol
    GatAprovided by FlyBase
    Official Full Name
    Glutamyl-tRNA amidotransferase, subunit Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260779
    Locus tag
    Dmel_CG6007
    See related
    AllianceGenome:FB:FBgn0260779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0929/02; bene; benedict; CG6007; Dmel\CG6007; gatA; GATA; l(3)S092902
    Summary
    Enables serine hydrolase activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See GatA in Genome Data Viewer
    Location:
    91E4-91E4; 3-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19026174..19028857, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14851896..14854579, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NP15.6 Neighboring gene Pyrroline 5-carboyxlate reductase Neighboring gene Prp18 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units. Misener SR, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858562
    2. Identification and analysis of mutations in bob, Doa and eight new genes required for oocyte specification and development in Drosophila melanogaster. Morris JZ, et al. Genetics, 2003 Aug. PMID 12930750, Free PMC Article
    3. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues. Morris JZ, et al. Genetics, 2008 Feb. PMID 18245325, Free PMC Article
    4. Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. Ameres SL, et al. RNA, 2011 Jan. PMID 21106652, Free PMC Article
    5. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Liao TS, et al. Genetics, 2006 Sep. PMID 16849596, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gatA expression is required cell autonomously for normal growth. The gatA gene is widely expressed in mitotic and endoreplicating tissues.
      Title: Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glutamyl-tRNA amidotransferase, subunit A
    Names
    CG6007-PA
    GatA-PA
    Glutamyl-tRNA(Gln) amidotransferase, subunit A
    benedict
    gatA
    glutamyl-tRNA amidotransferase A
    glutamyl-tRNA amidotransferase subunit A
    lethal (3) S092902
    NP_650775.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19026174..19028857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142518.4 → NP_650775.2  Glutamyl-tRNA amidotransferase, subunit A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650775.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R50, Q9U9C8, Q9VE09
      UniProtKB/TrEMBL
      H5V8A8
      Related
      FBpp0083132
      Conserved Domains (2) summary
      PRK00012
      Location:18 → 490
      gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed
      PRK07488
      Location:8 → 491
      PRK07488; indole acetimide hydrolase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KLE9 Q7KLE9
    Q9VE09.1 Q9VE09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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