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    Uxt Uxt prefoldin-like subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34893, updated on 10-May-2024

    Summary

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    Official Symbol
    Uxtprovided by FlyBase
    Official Full Name
    Uxt prefoldin-like subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259982
    Locus tag
    Dmel_CG15266
    See related
    AllianceGenome:FB:FBgn0259982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS07295.5; br50; CG15266; Dmel\CG15266; l(2)35Cc; l(2)br50; l35Cc; uxt
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in chromatin. Orthologous to human UXT (ubiquitously expressed prefoldin like chaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Uxt in Genome Data Viewer
    Location:
    35C5-35C5; 2-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15256581..15257642)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15256581..15257642)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene down and out Neighboring gene DNA polymerase delta subunit 3 Neighboring gene yuri gagarin Neighboring gene Cullin 3 Neighboring gene UK114

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Pol32 in Drosophila melanogaster causes chromosome instability and suppresses variegation. Tritto P, et al. PLoS One, 2015. PMID 25826374, Free PMC Article
    2. A homolog of human transcription factor NF-X1 encoded by the Drosophila shuttle craft gene is required in the embryonic central nervous system. Stroumbakis ND, et al. Mol Cell Biol, 1996 Jan. PMID 8524296, Free PMC Article
    3. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Furukawa T, et al. Cell, 1992 Jun 26. PMID 1617729
    4. A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions. Cai Y, et al. EMBO J, 2001 Apr 2. PMID 11285234, Free PMC Article
    5. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Uxt prefoldin-like subunit
    Names
    CG15266-PA
    CG15266-PB
    Uxt-PA
    Uxt-PB
    lethal (2) 35Cc

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15256581..15257642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135900.4 → NP_609744.2  Uxt prefoldin-like subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609744.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NK93, Q9VJP9
      Related
      FBpp0080268
      Conserved Domains (1) summary
      cd00584
      Location:26 → 154
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

    2. NM_001273535.1 → NP_001260464.1  Uxt prefoldin-like subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260464.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NK93, Q9VJP9
      Conserved Domains (1) summary
      cd00584
      Location:26 → 154
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJP9 Q9VJP9

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