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    CG13690 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33213, updated on 19-Jun-2024

    Summary

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    Official Symbol
    CG13690provided by FlyBase
    Primary source
    FLYBASE:FBgn0031252
    Locus tag
    Dmel_CG13690
    See related
    AllianceGenome:FB:FBgn0031252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13690
    Summary
    Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG13690 in Genome Data Viewer
    Location:
    21C2-21C2; 2-0.7 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (418434..419652, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (418434..419652, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit B Neighboring gene Adaptor Protein complex 2, alpha subunit Neighboring gene ebi Neighboring gene Ribosomal protein LP1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Juvenile hormone membrane signaling phosphorylates USP and thus potentiates 20-hydroxyecdysone action in Drosophila. Gao Y, et al. Sci Bull (Beijing), 2022 Jan 30. PMID 36546012
    2. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Dimova DK, et al. Genes Dev, 2003 Sep 15. PMID 12975318, Free PMC Article
    3. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828
    4. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article
    5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, removal of RNA primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonuclease H2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13690-PA
    NP_608521.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      418434..419652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134677.4 → NP_608521.1  uncharacterized protein Dmel_CG13690 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V3V1, Q9VPP5
      UniProtKB/TrEMBL
      A0AP92, A0AP98, A0APA0, C0MJM8, C0MJN4, C0MJN5, C0MJN7
      Related
      FBpp0077750
      Conserved Domains (1) summary
      cd07181
      Location:73 → 295
      RNase_HII_eukaryota_like; Eukaryotic RNase HII
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPP5.1 Q9VPP5

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