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    ND-39 NADH dehydrogenase (ubiquinone) 39 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40272, updated on 10-May-2024

    Summary

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    Official Symbol
    ND-39provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 39 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037001
    Locus tag
    Dmel_CG6020
    See related
    AllianceGenome:FB:FBgn0037001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6020; Dmel\CG6020; dNDUFA9; GM13757p; Ndufa9; NDUFA9; NUEM
    Summary
    Predicted to enable catalytic activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and ubiquinone-6 biosynthetic process. Predicted to be part of mitochondrial respiratory chain complex I. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval muscle system; gastrula embryo; germ layer derivative; and visceral muscle primordium. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ND-39 in Genome Data Viewer
    Location:
    77C6-77C6; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20492082..20497084)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20485182..20490184)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene iso Glutaminyl cyclase Neighboring gene Zinc transporter 77C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Gospodaryov DV, et al. Biochim Biophys Acta, 2014 Nov. PMID 25124484
    2. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hegde VR, et al. Hum Mol Genet, 2014 Sep 1. PMID 24760769, Free PMC Article
    3. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Sanz A, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20435911, Free PMC Article
    4. Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster. Scialo F, et al. PLoS One, 2016. PMID 27570965, Free PMC Article
    5. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Paradis M, et al. Sci Adv, 2022 Jul 22. PMID 35867795, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquinone-6 biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 39 kDa subunit
    Names
    CG6020-PA
    CG6020-PB
    FBpp0077859
    NADH dehydrogenase
    NADH ubiquinone oxidoreductase 39 kDa
    NADH-ubiquinone oxidoreductase 39 kDa subunit
    NADH:ubiquinone oxidoreductase 39 kDa subunit
    ND-39-PA
    ND-39-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20492082..20497084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140977.2 → NP_649234.1  NADH dehydrogenase (ubiquinone) 39 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A024E3A5, Q9VPE2
      Related
      FBpp0077859
      Conserved Domains (2) summary
      cd05271
      Location:64 → 354
      NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
      pfam01370
      Location:66 → 282
      Epimerase; NAD dependent epimerase/dehydratase family

    2. NM_001275187.1 → NP_001262116.1  NADH dehydrogenase (ubiquinone) 39 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A024E3A5, Q9VPE2
      Conserved Domains (2) summary
      cd05271
      Location:64 → 354
      NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
      pfam01370
      Location:66 → 282
      Epimerase; NAD dependent epimerase/dehydratase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NN5 Q86NN5
    Q9VPE2 Q9VPE2

    Gene LinkOut

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