U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pph13 PvuII-PstI homology 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33239, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pph13provided by FlyBase
    Official Full Name
    PvuII-PstI homology 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0023489
    Locus tag
    Dmel_CG2819
    See related
    AllianceGenome:FB:FBgn0023489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    60Mun1; CG2819; Dmel\CG2819; hazy; Mu; pph13; PPH13
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in ocellus photoreceptor cell development; positive regulation of transcription by RNA polymerase II; and rhabdomere development. Located in nucleus. Is expressed in Bolwig organ primordium; adult optic lobe; photoreceptor; and photoreceptor cell. Human ortholog(s) of this gene implicated in X-linked lissencephaly 2; corpus callosum agenesis-abnormal genitalia syndrome; developmental and epileptic encephalopathy 1; and intellectual disability (multiple). Orthologous to several human genes including ARX (aristaless related homeobox). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pph13 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (577486..579549)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (577486..579549)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Inositol phosphate kinase 2 Neighboring gene coiled Neighboring gene Prothoracicotropic hormone Neighboring gene long non-coding RNA:CR46148 Neighboring gene Goosecoid Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans. Mahato S, et al. PLoS Genet, 2014 Jul. PMID 24991928, Free PMC Article
    2. Cross species analysis of Prominin reveals a conserved cellular role in invertebrate and vertebrate photoreceptor cells. Nie J, et al. Dev Biol, 2012 Nov 15. PMID 22960282
    3. Munster, a novel paired-class homeobox gene specifically expressed in the Drosophila larval eye. Goriely A, et al. Mech Dev, 1999 Oct. PMID 10525194
    4. Two temporal functions of Glass: Ommatidium patterning and photoreceptor differentiation. Liang X, et al. Dev Biol, 2016 Jun 1. PMID 27105580, Free PMC Article
    5. The power of the (imperfect) palindrome: Sequence-specific roles of palindromic motifs in gene regulation. Datta RR, et al. Bioessays, 2022 Apr. PMID 35195290, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors conclude that Glass can either directly or indirectly initiate the expression of most phototransduction proteins in a Hazy-independent manner, and that Hazy is mainly required for the maintenance of functional photoreceptors in adult flies.
      Title: Successive requirement of Glass and Hazy for photoreceptor specification and maintenance in Drosophila.
    2. Although Otd and Pph13 have been implicated in rhabdomere morphogenesis, we demonstrate that it is necessary to remove both factors to completely eliminate rhabdomere formation.
      Title: Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function.
    3. Data show that Pph13 is required for both rhabdomere morphogenesis and for the proper detection of light.
      Title: Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ocellus photoreceptor cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    PvuII-PstI homology 13
    Names
    CG2819-PA
    Pph13-PA
    hazy
    munster

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      577486..579549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057982.4 → NP_477330.1  PvuII-PstI homology 13 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0V5, Q9XZU0
      Related
      FBpp0077730
      Conserved Domains (1) summary
      pfam00046
      Location:14 → 66
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0V5 Q8T0V5
    Q9U5X2 Q9U5X2
    Q9XZU0 Q9XZU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools