Camkv CaM kinase-like vesicle-associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camkvprovided by RGD
Official Full Name: CaM kinase-like vesicle-associatedprovided by RGD
Primary source: RGD:621488
See related: Ensembl:ENSRNOG00000058938 AllianceGenome:RGD:621488
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 1G5
Summary: Enables calmodulin binding activity. Predicted to be involved in peptidyl-serine phosphorylation and regulation of modification of postsynaptic structure. Is active in postsynapse. Orthologous to human CAMKV (CaM kinase like vesicle associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 338.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117505439..117519785)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108626821..108641169)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116715755..116730061)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Camkv has a role in activity-dependent maintenance of dendritic spines
Title: The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of modification of postsynaptic structure	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caM kinase-like vesicle-associated protein

Names: vesicle-associated calmodulin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024000.1 → NP_076490.1 caM kinase-like vesicle-associated protein

See identical proteins and their annotated locations for NP_076490.1

Status: PROVISIONAL

Source sequence(s)

L22557

UniProtKB/Swiss-Prot

Q63092

UniProtKB/TrEMBL

A0A0G2K1R5

Related

ENSRNOP00000071953.1, ENSRNOT00000090239.2

Conserved Domains (2) summary

PRK12495
Location:368 → 445

PRK12495; hypothetical protein; Provisional

cd14088
Location:22 → 286

STKc_CaMK_like; Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases