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Ctnnb1 catenin beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84353, updated on 2-May-2024

Summary

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Official Symbol: Ctnnb1provided by RGD
Official Full Name: catenin beta 1provided by RGD
Primary source: RGD:70487
See related: Ensembl:ENSRNOG00000054172 AllianceGenome:RGD:70487
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Catnb
Summary: Enables cadherin binding activity; ionotropic glutamate receptor binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and nuclear membrane. Part of protein-containing complex. Colocalizes with neuron projection. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease and colorectal cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1354.8), Lung (RPKM 1330.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Ctnnb1 in Genome Data Viewer

Location:: 8q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (129517576..129544661)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (120640008..120667110)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (129601511..129628378)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/beta-Catenin.
Title: LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/β-Catenin.
Upregulation of miR-200a improves ureteral obstruction-induced renal fibrosis via GAB1/Wnt/beta-catenin signaling.
Title: Upregulation of miR-200a improves ureteral obstruction-induced renal fibrosis via GAB1/Wnt/β-catenin signaling.
E-cadherin/beta-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis.
Title: E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis.
Restoration of miR-328a-5p function curtails hypoxic pulmonary hypertension through a mechanism involving PIN1/GSK3beta/beta-catenin axis.
Title: Restoration of miR-328a-5p function curtails hypoxic pulmonary hypertension through a mechanism involving PIN1/GSK3β/β-catenin axis.
Human neural stem cells repress glioma cell progression in a paracrine manner by downregulating the Wnt/beta-catenin signalling pathway.
Title: Human neural stem cells repress glioma cell progression in a paracrine manner by downregulating the Wnt/β-catenin signalling pathway.
CREB-binding protein and HIF-1alpha/beta-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
Title: CREB-binding protein and HIF-1α/β-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia-reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of beta-catenin.
Title: FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia-reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of β-catenin.
beta-catenin ameliorates myocardial infarction by preventing YAP-associated apoptosis.
Title: β-catenin ameliorates myocardial infarction by preventing YAP-associated apoptosis.
Exosome from BMMSC Attenuates Cardiopulmonary Bypass-Induced Acute Lung Injury Via YAP/beta-Catenin Pathway: Downregulation of Pyroptosis.
Title: Exosome from BMMSC Attenuates Cardiopulmonary Bypass-Induced Acute Lung Injury Via YAP/β-Catenin Pathway: Downregulation of Pyroptosis.
beta-Catenin promotes long-term survival and angiogenesis of peripheral blood mesenchymal stem cells via the Oct4 signaling pathway.
Title: β-Catenin promotes long-term survival and angiogenesis of peripheral blood mesenchymal stem cells via the Oct4 signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (227)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ctnnb1 (e-PCR), detects polymorphism
- UniSTS:516100

Ctnnb1 (e-PCR), detects polymorphism
- UniSTS:508427

PMC316619P1 (e-PCR)
- UniSTS:273018

Ctnnb1 (e-PCR), detects polymorphism
- UniSTS:547206

PMC21165P1 (e-PCR)
- UniSTS:272017

Catnb (e-PCR), detects polymorphism
- UniSTS:141239

RH133995 (e-PCR)
- UniSTS:217277

RH140639 (e-PCR)
- UniSTS:222708

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-catenin binding	IEA Inferred from Electronic Annotation more info
enables alpha-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables delta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in acinar cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acinar cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in adherens junction assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adherens junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ development	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in astrocyte-dopaminergic neuron signaling	IEA Inferred from Electronic Annotation more info
involved_in astrocyte-dopaminergic neuron signaling	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in bone remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone resorption	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to indole-3-methanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to indole-3-methanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to indole-3-methanol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin-like growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin-like growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lithium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system vasculogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in cranial ganglion development	IEA Inferred from Electronic Annotation more info
involved_in cranial ganglion development	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in dorsal root ganglion development	IEA Inferred from Electronic Annotation more info
involved_in dorsal root ganglion development	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
involved_in ectoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ectoderm development	ISO Inferred from Sequence Orthology more info
involved_in embryonic axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic axis specification	ISO Inferred from Sequence Orthology more info
involved_in embryonic brain development	IEA Inferred from Electronic Annotation more info
involved_in embryonic brain development	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic foregut morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic foregut morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal limb joint morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal limb joint morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm formation	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endodermal cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in epididymis development	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell differentiation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in epithelial tube branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of blood-brain barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of blood-retinal barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of blood-retinal barrier	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in fungiform papilla formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fungiform papilla formation	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glandular epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glial cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glial cell fate determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair cycle process	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hair follicle placode formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hair follicle placode formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hindbrain development	IEA Inferred from Electronic Annotation more info
involved_in hindbrain development	ISO Inferred from Sequence Orthology more info
involved_in hypothalamus development	IEA Inferred from Electronic Annotation more info
involved_in hypothalamus development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in lens morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of lung epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lung induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung induction	ISO Inferred from Sequence Orthology more info
involved_in lung-associated mesenchyme development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in male genitalia development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell proliferation involved in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	ISO Inferred from Sequence Orthology more info
involved_in midbrain dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in midbrain dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of myoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle, embryonic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle, embryonic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle, embryonic	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nephron tubule formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nephron tubule formation	ISO Inferred from Sequence Orthology more info
involved_in neural plate development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural plate development	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron fate determination	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in oocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte development	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in oviduct development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oviduct development	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of determination of dorsal identity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of determination of dorsal identity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of centriole-centriole cohesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of centriole-centriole cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centromeric sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of centromeric sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of centromeric sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of nephron tubule epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of secondary heart field cardioblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of timing of anagen	IEA Inferred from Electronic Annotation more info
involved_in regulation of timing of anagen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in renal inner medulla development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal inner medulla development	ISO Inferred from Sequence Orthology more info
involved_in renal outer medulla development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal outer medulla development	ISO Inferred from Sequence Orthology more info
involved_in renal vesicle formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in sympathetic ganglion development	IEA Inferred from Electronic Annotation more info
involved_in sympathetic ganglion development	ISO Inferred from Sequence Orthology more info
involved_in sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in trachea formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trachea formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
part_of Scrib-APC-beta-catenin complex	IEA Inferred from Electronic Annotation more info
part_of Scrib-APC-beta-catenin complex	ISO Inferred from Sequence Orthology more info
part_of Wnt signalosome	IEA Inferred from Electronic Annotation more info
part_of Wnt signalosome	ISO Inferred from Sequence Orthology more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	ISS Inferred from Sequence or Structural Similarity more info
part_of beta-catenin-ICAT complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-ICAT complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin-TCF7L2 complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin-TCF7L2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IEA Inferred from Electronic Annotation more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
part_of catenin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
part_of euchromatin	IEA Inferred from Electronic Annotation more info
part_of euchromatin	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in fascia adherens	IEA Inferred from Electronic Annotation more info
located_in fascia adherens	ISO Inferred from Sequence Orthology more info
part_of flotillin complex	IEA Inferred from Electronic Annotation more info
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density, intracellular component	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone cytoplasmic component	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: catenin beta-1

Names: beta-catenin; catenin (cadherin associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053357.2 → NP_445809.2 catenin beta-1

See identical proteins and their annotated locations for NP_445809.2

Status: PROVISIONAL

Source sequence(s)

AF121265

UniProtKB/Swiss-Prot

Q9WU82

Conserved Domains (3) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:399 → 518

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

129517576..129544661

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266229.1 → XP_063122299.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428
XM_039082208.2 → XP_038938136.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428

Related

ENSRNOP00000094665.1

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_039082209.2 → XP_038938137.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428

Related

ENSRNOP00000068620.1

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_039082207.2 → XP_038938135.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_063266226.1 → XP_063122296.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428
XM_063266224.1 → XP_063122294.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428
XM_063266227.1 → XP_063122297.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428
XM_063266225.1 → XP_063122295.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428
XM_063266228.1 → XP_063122298.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT93, A6I428