Tcap titin-cap [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tcapprovided by RGD
Official Full Name: titin-capprovided by RGD
Primary source: RGD:1592387
See related: Ensembl:ENSRNOG00000068106 AllianceGenome:RGD:1592387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including BMP binding activity; cytoskeletal protein binding activity; and titin Z domain binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in several processes, including cardiac muscle hypertrophy in response to stress; myofibril assembly; and striated muscle contraction. Predicted to act upstream of or within adult heart development; otic vesicle formation; and somitogenesis. Predicted to be located in Z disc. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2G and hypertrophic cardiomyopathy 25. Orthologous to human TCAP (titin-cap). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1569.8) and Heart (RPKM 1192.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (83878006..83879174)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (83381719..83382887)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86337705..86338414)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients.
Title: Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.
data suggest that telethonin is a substrate of the ubiquitin-proteasome system during soleus muscle atrophy.
Title: Coordinate expression of the 19S regulatory complex and evidence for ubiquitin-dependent telethonin degradation in the unloaded soleus muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables FATZ binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables titin Z domain binding	ISO Inferred from Sequence Orthology more info
enables titin binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult heart development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in detection of muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in otic vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in sarcomerogenesis	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle myosin thick filament assembly	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle thin filament assembly	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in I band	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: telethonin

Names: titin cap protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.