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    Snf8 SNF8 subunit of ESCRT-II [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287645, updated on 2-May-2024

    Summary

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    Official Symbol
    Snf8provided by RGD
    Official Full Name
    SNF8 subunit of ESCRT-IIprovided by RGD
    Primary source
    RGD:1310144
    See related
    Ensembl:ENSRNOG00000006500 AllianceGenome:RGD:1310144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    D11moh34; RGD1310144
    Summary
    Predicted to enable several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosomal transport; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including endosome; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of ESCRT II complex and transcription regulator complex. Orthologous to human SNF8 (SNF8 subunit of ESCRT-II). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 132.1), Kidney (RPKM 114.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snf8 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81481054..81493430)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (80984337..80996724)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83856331..83868621)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 mRNA binding protein 1 Neighboring gene gastric inhibitory polypeptide Neighboring gene proteasome assembly chaperone 4, pseudogene 2 Neighboring gene high mobility group protein B1-like Neighboring gene ubiquitin-conjugating enzyme E2Z Neighboring gene ATP synthase membrane subunit c locus 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II. Schmidt AE, et al. J Biol Chem, 1999 Jul 30. PMID 10419521
    2. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. Carrasquillo R, et al. BMC Cell Biol, 2012 Nov 21. PMID 23171048, Free PMC Article
    3. ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly. Ghoujal B, et al. Biol Cell, 2012 Dec. PMID 22978549
    4. How do ESCRT proteins control autophagy? Rusten TE, et al. J Cell Sci, 2009 Jul 1. PMID 19535733
    5. RILP is required for the proper morphology and function of late endosomes. Progida C, et al. J Cell Sci, 2007 Nov 1. PMID 17959629

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105799

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein complex stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT II complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT II complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar-sorting protein SNF8
    Names
    EAP30 subunit of ELL complex
    ELL-associated protein of 30 kDa
    ESCRT-II complex subunit VPS22
    SNF8, ESCRT-II complex subunit, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007804.2 → NP_001007805.1  vacuolar-sorting protein SNF8

      See identical proteins and their annotated locations for NP_001007805.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5RK19
      UniProtKB/TrEMBL
      A0A8I6APW2, A6HIC5, A6HIC6
      Related
      ENSRNOP00000008964.2, ENSRNOT00000008964.5
      Conserved Domains (1) summary
      pfam04157
      Location:7 → 225
      EAP30; EAP30/Vps36 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81481054..81493430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268726.1 → XP_063124796.1  vacuolar-sorting protein SNF8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7G8

    2. XM_063268727.1 → XP_063124797.1  vacuolar-sorting protein SNF8 isoform X2

    RNA

    1. XR_005489752.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RK19.1 GenPept UniProtKB/Swiss-Prot:Q5RK19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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