Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrig1provided by RGD
Official Full Name: leucine-rich repeats and immunoglobulin-like domains 1provided by RGD
Primary source: RGD:1306788
See related: Ensembl:ENSRNOG00000012952 AllianceGenome:RGD:1306788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 256.3), Muscle (RPKM 152.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q34

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (128687723..128788219, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (127130899..127230956, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (126615998..126717434, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

D4Rat188 (e-PCR), detects polymorphism
- UniSTS:227746

D4Rat236 (e-PCR), detects polymorphism
- UniSTS:227780

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within hair cycle process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within innervation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otolith morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: leucine-rich repeats and immunoglobulin-like domains protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427801.1 → NP_001414730.1 leucine-rich repeats and immunoglobulin-like domains protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

M0RB60

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

128687723..128788219 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286082.1 → XP_063142152.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1
XM_039108763.2 → XP_038964691.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

Conserved Domains (5) summary

pfam01463
Location:8 → 32

LRRCT; Leucine rich repeat C-terminal domain

pfam07679
Location:235 → 322

I-set; Immunoglobulin I-set domain

pfam13927
Location:36 → 123

Ig_3; Immunoglobulin domain

cd00096
Location:243 → 246

Ig; Ig strand A' [structural motif]

cd05763
Location:142 → 232

IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains