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    Pprc1 PPARG related coactivator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294007, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pprc1provided by RGD
    Official Full Name
    PPARG related coactivator 1provided by RGD
    Primary source
    RGD:1309688
    See related
    Ensembl:ENSRNOG00000018561 AllianceGenome:RGD:1309688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 57.0), Adrenal (RPKM 43.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pprc1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254851136..254867570)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244901985..244918587)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265809892..265826319)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene LIM domain binding 1 Neighboring gene LIM domain binding 1 like Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Names
    peroxisome proliferative activated receptor, gamma, coactivator-related 1
    peroxisome proliferator-activated receptor gamma, coactivator-related 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106363.1 → NP_001099833.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1

      See identical proteins and their annotated locations for NP_001099833.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/TrEMBL
      A6JHK7
      Conserved Domains (1) summary
      cd12624
      Location:1515 → 1605
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254851136..254867570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589040.3 → XP_017444529.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

      UniProtKB/TrEMBL
      A6JHK8

    2. XM_063287211.1 → XP_063143281.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

      UniProtKB/TrEMBL
      A6JHK8

    3. XM_063287217.1 → XP_063143287.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

      UniProtKB/TrEMBL
      A6JHK8

    4. XM_063287219.1 → XP_063143289.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X15

      UniProtKB/TrEMBL
      A6JHK8

    5. XM_063287221.1 → XP_063143291.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X16

      UniProtKB/TrEMBL
      A6JHK8

    6. XM_006231454.5 → XP_006231516.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

      Conserved Domains (1) summary
      cd12624
      Location:1514 → 1604
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    7. XM_006231455.5 → XP_006231517.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

      Conserved Domains (1) summary
      cd12624
      Location:1513 → 1603
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    8. XM_039109074.2 → XP_038965002.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

      Conserved Domains (2) summary
      PHA03247
      Location:597 → 1082
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1482 → 1572
      RRM_PRC; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    9. XM_006231451.5 → XP_006231513.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZRG8
      Related
      ENSRNOP00000025222.8
      Conserved Domains (1) summary
      cd12624
      Location:1516 → 1606
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    10. XM_006231452.5 → XP_006231514.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

      Conserved Domains (1) summary
      cd12624
      Location:1515 → 1605
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    11. XM_063287192.1 → XP_063143262.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

    12. XM_063287198.1 → XP_063143268.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    13. XM_063287201.1 → XP_063143271.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

    14. XM_063287203.1 → XP_063143273.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

    15. XM_006231453.4 → XP_006231515.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

      UniProtKB/TrEMBL
      D3ZRG8
      Conserved Domains (1) summary
      cd12624
      Location:1514 → 1604
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    16. XM_006231456.5 → XP_006231518.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

      Conserved Domains (1) summary
      cd12624
      Location:1508 → 1598
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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