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    Ankhd1 ankyrin repeat and KH domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100529260, updated on 6-Jun-2024

    Summary

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    Symbol
    Ankhd1provided by RGD
    Full Name
    ankyrin repeat and KH domain containing 1provided by RGD
    Primary source
    RGD:4892133
    See related
    Ensembl:ENSRNOG00000030247 AllianceGenome:RGD:4892133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Orthologous to human ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough) and ANKHD1 (ankyrin repeat and KH domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 175.9), Thymus (RPKM 161.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankhd1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28436296..28534954)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28161882..28260917)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29386906..29485611)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene heparin-binding EGF-like growth factor Neighboring gene solute carrier family 4 member 9 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene steroid receptor RNA activator 1 Neighboring gene amyloid beta precursor protein binding family B member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
    2. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and KH domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204053.2 → NP_001190982.2  ankyrin repeat and KH domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      E9PTK9
      Related
      ENSRNOP00000089900.1, ENSRNOT00000096723.1

    2. NM_001415723.1 → NP_001402652.1  ankyrin repeat and KH domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      E9PTK9
      Related
      ENSRNOP00000024825.6, ENSRNOT00000024825.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28436296..28534954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277051.1 → XP_063133121.1  ankyrin repeat and KH domain-containing protein 1 isoform X2

    2. XM_063277050.1 → XP_063133120.1  ankyrin repeat and KH domain-containing protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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