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    Mettl18 methyltransferase like 18 [ Mus musculus (house mouse) ]

    Gene ID: 69962, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mettl18provided by MGI
    Official Full Name
    methyltransferase like 18provided by MGI
    Primary source
    MGI:MGI:1917212
    See related
    Ensembl:ENSMUSG00000041396 AllianceGenome:MGI:1917212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810422O20Rik
    Summary
    Predicted to enable heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Predicted to be involved in protein methylation; regulation of gene expression; and regulation of ribosome biogenesis. Predicted to act upstream of or within methylation. Predicted to be located in cytosol and nucleolus. Predicted to be part of protein-containing complex. Orthologous to human METTL18 (methyltransferase like 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.4), bladder adult (RPKM 2.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl18 in Genome Data Viewer
    Location:
    1 H2.2; 1 71.3 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163822458..163824812)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163994889..163997243)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene STARR-seq mESC enhancer starr_02858 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_02859 Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene STARR-seq mESC enhancer starr_02860 Neighboring gene STARR-seq mESC enhancer starr_02864 Neighboring gene STARR-positive B cell enhancer ABC_E7768 Neighboring gene STARR-positive B cell enhancer ABC_E3322 Neighboring gene STARR-positive B cell enhancer ABC_E10052 Neighboring gene STARR-positive B cell enhancer ABC_E7769 Neighboring gene STARR-positive B cell enhancer ABC_E11099 Neighboring gene STARR-positive B cell enhancer ABC_E11100 Neighboring gene selectin, endothelial cell Neighboring gene selectin, lymphocyte

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-L-histidine N-tele-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-L-histidine N-tele-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-histidine methylation, to form tele-methylhistidine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine monomethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histidine protein methyltransferase 1 homolog
    Names
    methyltransferase-like protein 18
    NP_001342061.1
    NP_081555.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355132.1 → NP_001342061.1  histidine protein methyltransferase 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AC110499, AK013137, AK139786, BC052693
      Consensus CDS
      CCDS15431.1
      UniProtKB/Swiss-Prot
      Q810I8, Q9CZ09
      Related
      ENSMUSP00000107116.2, ENSMUST00000111490.2
      Conserved Domains (1) summary
      cl17173
      Location:155 → 314
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_027279.3 → NP_081555.2  histidine protein methyltransferase 1 homolog

      See identical proteins and their annotated locations for NP_081555.2

      Status: VALIDATED

      Source sequence(s)
      AC110499, AK139786, BC050143
      Consensus CDS
      CCDS15431.1
      UniProtKB/Swiss-Prot
      Q810I8, Q9CZ09
      Related
      ENSMUSP00000048636.8, ENSMUST00000045694.14
      Conserved Domains (1) summary
      cl17173
      Location:155 → 314
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      163822458..163824812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ09.2 GenPept UniProtKB/Swiss-Prot:Q9CZ09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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