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    Zc3h15 zinc finger CCCH-type containing 15 [ Mus musculus (house mouse) ]

    Gene ID: 69082, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zc3h15provided by MGI
    Official Full Name
    zinc finger CCCH-type containing 15provided by MGI
    Primary source
    MGI:MGI:1919747
    See related
    Ensembl:ENSMUSG00000027091 AllianceGenome:MGI:1919747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FM22; Ierepo4; 1700006A17Rik; 1810012H02Rik; 2610312B22Rik
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZC3H15 (zinc finger CCCH-type containing 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 53.2), CNS E18 (RPKM 33.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h15 in Genome Data Viewer
    Location:
    2 D; 2 49.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83474922..83494961)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83644578..83664617)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04981 Neighboring gene fructose-bisphosphate aldolase A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04983 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04984 Neighboring gene STARR-seq mESC enhancer starr_04985 Neighboring gene STARR-positive B cell enhancer ABC_E11141 Neighboring gene STARR-positive B cell enhancer ABC_E11142 Neighboring gene STARR-positive B cell enhancer ABC_E7831 Neighboring gene STARR-positive B cell enhancer mm9_chr2:83505584-83505885 Neighboring gene STARR-seq mESC enhancer starr_04989 Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2039 Neighboring gene STARR-positive B cell enhancer ABC_E7832 Neighboring gene integrin alpha V Neighboring gene family with sequence similarity 171, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subtraction cloning and initial characterization of novel epo-immediate response genes. Gregory RC, et al. Cytokine, 2000 Jul. PMID 10880228
    2. Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. Ishikawa K, et al. Genes Cells, 2005 Feb. PMID 15676025
    3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 15
    Names
    DRG family-regulatory protein 1
    epo-immediate response gene protein FM22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026934.3 → NP_081210.2  zinc finger CCCH domain-containing protein 15

      See identical proteins and their annotated locations for NP_081210.2

      Status: PROVISIONAL

      Source sequence(s)
      AL772301, BX294652
      Consensus CDS
      CCDS16180.1
      UniProtKB/Swiss-Prot
      Q3TIV5, Q3TWQ0, Q3U855, Q8K2B6, Q8K346, Q9CVM4, Q9DAP2
      Related
      ENSMUSP00000080301.7, ENSMUST00000081591.7
      Conserved Domains (1) summary
      cl25637
      Location:1 → 325
      DFRP_C; DRG Family Regulatory Proteins, Tma46

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      83474922..83494961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027023.1: Suppressed sequence

      Description
      NM_027023.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TIV5.2 GenPept UniProtKB/Swiss-Prot:Q3TIV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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