Cox5a cytochrome c oxidase subunit 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox5aprovided by RGD
Official Full Name: cytochrome c oxidase subunit 5Aprovided by RGD
Primary source: RGD:620607
See related: AllianceGenome:RGD:620607
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 5197.2), Muscle (RPKM 3784.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (66818284..66829691)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (57922374..57933781)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62298358..62309765)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a.
Title: MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a.
COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation.
Title: COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation.
Novel observations indicate that Cox5a hypermethylation is associated with mitochondrial dysfunction in skeletal muscle of high-fat diet-induced insulin resistant rats.
Title: Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats.
Report loss of Cox5a subunits in ischemia-reperfusion injury and exacerbation of subunit loss by PKC-epsilon inhibition.
Title: Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cox5a (e-PCR), detects polymorphism
- UniSTS:531499

Cox5a (e-PCR), detects polymorphism
- UniSTS:141381

UniSTS:141382 (e-PCR)
- UniSTS:141382

Cox5a (e-PCR), detects polymorphism
- UniSTS:141382

AA959768 (e-PCR)
- UniSTS:160149

RH134568 (e-PCR)
- UniSTS:217848

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytochrome-c oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytochrome-c oxidase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex IV	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 5A, mitochondrial

Names: cytochrome c oxidase polypeptide Va; cytochrome c oxidase, subunit Va

NP_665726.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145783.1 → NP_665726.1 cytochrome c oxidase subunit 5A, mitochondrial precursor

See identical proteins and their annotated locations for NP_665726.1

Status: PROVISIONAL

Source sequence(s)

X15030

UniProtKB/Swiss-Prot

P11240

UniProtKB/TrEMBL

A0A8L2QDJ0, A6J4V5

Conserved Domains (1) summary

cd00923
Location:41 → 142

Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...