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    Prmt2 protein arginine methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499420, updated on 19-Jun-2024

    Summary

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    Symbol
    Prmt2provided by RGD
    Full Name
    protein arginine methyltransferase 2provided by RGD
    Primary source
    RGD:1565519
    See related
    Ensembl:ENSRNOG00000001297 AllianceGenome:RGD:1565519
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hrmt1l1
    Summary
    Predicted to enable several functions, including beta-catenin binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Biomarker of asthma. Orthologous to human PRMT2 (protein arginine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 49.6), Thymus (RPKM 49.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prmt2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12391388..12420096)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12394748..12420643)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13154513..13212613)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene disco-interacting protein 2 homolog A Neighboring gene uncharacterized LOC134483887 Neighboring gene U6 spliceosomal RNA Neighboring gene S100 calcium binding protein B Neighboring gene microRNA 678 Neighboring gene solute carrier family 5 member 4 Neighboring gene solute carrier family 5 (neutral amino acid transporters, system A), member 4b Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Iwasaki H, et al. Circ Res, 2010 Oct 15. PMID 20798359, Free PMC Article
    2. beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Blythe SA, et al. Dev Cell, 2010 Aug 17. PMID 20708585, Free PMC Article
    3. PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. Meyer R, et al. J Steroid Biochem Mol Biol, 2007 Oct. PMID 17587566
    4. [Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma]. Sun QZ, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2010 Apr. PMID 20423833
    5. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Kzhyshkowska J, et al. Biochem J, 2001 Sep 1. PMID 11513728, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation.
      Title: The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear progesterone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein arginine N-methyltransferase 2
    Names
    HMT1 hnRNP methyltransferase-like 1
    NP_001020315.1
    XP_038954937.1
    XP_038954938.1
    XP_063135531.1
    XP_063135532.1
    XP_063135533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025144.1 → NP_001020315.1  protein arginine N-methyltransferase 2

      See identical proteins and their annotated locations for NP_001020315.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079112
      UniProtKB/TrEMBL
      A0A9K3Y6N8, F1LMD8, Q6AYB9
      Related
      ENSRNOP00000039976.3, ENSRNOT00000050531.4
      Conserved Domains (2) summary
      cd02440
      Location:153 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:46 → 98
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12391388..12420096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279461.1 → XP_063135531.1  protein arginine N-methyltransferase 2 isoform X1

    2. XM_063279462.1 → XP_063135532.1  protein arginine N-methyltransferase 2 isoform X1

    3. XM_039099010.2 → XP_038954938.1  protein arginine N-methyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A9K3Y6N8, F1LMD8, Q6AYB9
      Conserved Domains (2) summary
      cd02440
      Location:153 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:46 → 98
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2

    4. XM_039099009.2 → XP_038954937.1  protein arginine N-methyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A9K3Y6N8, F1LMD8, Q6AYB9
      Conserved Domains (2) summary
      cd02440
      Location:153 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:46 → 98
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2

    5. XM_063279463.1 → XP_063135533.1  protein arginine N-methyltransferase 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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