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    Usp33 ubiquitin specific peptidase 33 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310960, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Usp33provided by RGD
    Official Full Name
    ubiquitin specific peptidase 33provided by RGD
    Primary source
    RGD:1307848
    See related
    Ensembl:ENSRNOG00000011294 AllianceGenome:RGD:1307848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cysteine-type peptidase activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including centrosome duplication; protein deubiquitination; and protein stabilization. Predicted to be located in several cellular components, including centrosome; focal adhesion; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human USP33 (ubiquitin specific peptidase 33). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 271.8), Brain (RPKM 265.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp33 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243938958..243988424)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241283209..241328479)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257567179..257602817)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein) Neighboring gene uncharacterized LOC120100974 Neighboring gene mitoguardin 1 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene adenylate kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus. Thorne C, et al. Traffic, 2011 Nov. PMID 21801292
    2. The solution structure of the ZnF UBP domain of USP33/VDU1. Allen MD, et al. Protein Sci, 2007 Sep. PMID 17766394, Free PMC Article
    3. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Fekete C, et al. Endocrinology, 2007 Oct. PMID 17628004
    4. Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary. Zhang X, et al. Biol Trace Elem Res, 2016 Dec. PMID 27156111
    5. Midline crossing and Slit responsiveness of commissural axons require USP33. Yuasa-Kawada J, et al. Nat Neurosci, 2009 Sep. PMID 19684588, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis.
      Title: Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary.
    2. Correlation between relative mRNA levels of WSB-1 and USP-33 in numerous tissues that do not express type 2 deiodinase(D2) suggests that these ubiquitin-related enzymes share additional substrates besides D2.
      Title: Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 33
    Names
    ubiquitin specific protease 33
    NP_001401992.1
    XP_038958425.1
    XP_038958426.1
    XP_063138059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415063.1 → NP_001401992.1  ubiquitin carboxyl-terminal hydrolase 33

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AEH4, F1LPJ7
      Related
      ENSRNOP00000060372.3, ENSRNOT00000066125.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243938958..243988424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281989.1 → XP_063138059.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEH4, F1LPJ7

    2. XM_039102497.2 → XP_038958425.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEH4
      Conserved Domains (4) summary
      smart00695
      Location:799 → 883
      DUSP; Domain in ubiquitin-specific proteases
      pfam00443
      Location:153 → 671
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 89
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:693 → 762
      DUSP; DUSP domain

    3. XM_039102498.2 → XP_038958426.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

      UniProtKB/TrEMBL
      A6HWL4
      Conserved Domains (3) summary
      pfam00443
      Location:153 → 679
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 89
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:701 → 770
      DUSP; DUSP domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017379.1: Suppressed sequence

      Description
      NM_001017379.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

    2. NM_001191094.1: Suppressed sequence

      Description
      NM_001191094.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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