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    ENDOG endonuclease G [ Bos taurus (cattle) ]

    Gene ID: 327707, updated on 6-Jun-2024

    Summary

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    Official Symbol
    ENDOGprovided by VGNC
    Official Full Name
    endonuclease Gprovided by VGNC
    Primary source
    VGNC:VGNC:28491
    See related
    BGD:BT14492
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ENDOG in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (99293097..99296823)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104973489 Neighboring gene TBC1 domain family member 13 Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene uncharacterized LOC132346505 Neighboring gene kynurenine aminotransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosis. Schäfer P, et al. J Mol Biol, 2004 Apr 23. PMID 15066427
    2. Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria. Gerschenson M, et al. Nucleic Acids Res, 1995 Jan 11. PMID 7870594, Free PMC Article
    3. Primers for mitochondrial DNA replication generated by endonuclease G. Côté J, et al. Science, 1993 Aug 6. PMID 7688144
    4. Reproducible high yield sequencing of proteins electrophoretically separated and transferred to an inert support. Moos M Jr, et al. J Biol Chem, 1988 May 5. PMID 3360771
    5. EXOG, a novel paralog of Endonuclease G in higher eukaryotes. Cymerman IA, et al. Nucleic Acids Res, 2008 Mar. PMID 18187503, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the mechanism of catalysis and substrate binding by the apoptotic mitochondrial nuclease EndoG, which belongs to the large family of DNA/RNA non-specific betabetaalpha-Me-finger nucleases.
      Title: Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA endodeoxyribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endonuclease G, mitochondrial
    Names
    endo G
    NP_787017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175823.3 → NP_787017.1  endonuclease G, mitochondrial precursor

      See identical proteins and their annotated locations for NP_787017.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134634
      UniProtKB/Swiss-Prot
      A4IFL3, P38447
      UniProtKB/TrEMBL
      A0A452DIJ1
      Conserved Domains (1) summary
      smart00477
      Location:80 → 286
      NUC; DNA/RNA non-specific endonuclease

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      99293097..99296823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38447.1 GenPept UniProtKB/Swiss-Prot:P38447

    Gene LinkOut

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    Research Materials