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    SOCS1 suppressor of cytokine signaling 1 [ Gallus gallus (chicken) ]

    Gene ID: 416630, updated on 5-Mar-2024

    Summary

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    Symbol
    SOCS1provided by CGNC
    Full Name
    suppressor of cytokine signaling 1provided by CGNC
    Primary source
    CGNC:5410
    See related
    Ensembl:ENSGALG00010019269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SOCS1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (8952774..8955462)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (8949681..8952369)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417201 Neighboring gene small integral membrane protein 10 like 1 Neighboring gene cytohesin 3 Neighboring gene uncharacterized LOC121106843 Neighboring gene RecQ mediated genome instability 2 Neighboring gene C-type lectin domain family 16 member A Neighboring gene Dexi homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells. Giotis ES, et al. Sci Rep, 2017 Dec 13. PMID 29235573, Free PMC Article
    2. The molecular basis of JAK/STAT inhibition by SOCS1. Liau NPD, et al. Nat Commun, 2018 Apr 19. PMID 29674694, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137648.1 → NP_001131120.1  suppressor of cytokine signaling 1

      See identical proteins and their annotated locations for NP_001131120.1

      Status: PROVISIONAL

      Source sequence(s)
      EF554725
      UniProtKB/TrEMBL
      B6RCQ2
      Conserved Domains (2) summary
      cd10382
      Location:64 → 161
      SH2_SOCS1; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03735
      Location:165 → 207
      SOCS_SOCS1; SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      8952774..8955462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294233.4 → XP_015149719.1  suppressor of cytokine signaling 1 isoform X1

      UniProtKB/TrEMBL
      B6RCQ2
      Related
      ENSGALP00010027754.1, ENSGALT00010046596.1
      Conserved Domains (2) summary
      cd10382
      Location:64 → 161
      SH2_SOCS1; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03735
      Location:165 → 207
      SOCS_SOCS1; SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the ...

    2. XM_046900653.1 → XP_046756609.1  suppressor of cytokine signaling 1 isoform X1

      UniProtKB/TrEMBL
      B6RCQ2
      Related
      ENSGALP00010027751.1, ENSGALT00010046593.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      8949681..8952369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046927472.1 → XP_046783428.1  suppressor of cytokine signaling 1 isoform X1

      UniProtKB/TrEMBL
      B6RCQ2

    2. XM_046927473.1 → XP_046783429.1  suppressor of cytokine signaling 1 isoform X1

      UniProtKB/TrEMBL
      B6RCQ2
    Nucleotide Protein Strain
    Heading Accession and Version

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