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    Septin11 septin 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305227, updated on 2-May-2024

    Summary

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    Official Symbol
    Septin11provided by RGD
    Official Full Name
    septin 11provided by RGD
    Primary source
    RGD:1307405
    See related
    Ensembl:ENSRNOG00000002182 AllianceGenome:RGD:1307405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sept11
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization of symmetric synapse. Orthologous to human SEPTIN11 (septin 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 177.5), Brain (RPKM 165.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Septin11 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (15119760..15275222, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (14844759..14990856, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (16369544..16405645, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3, pseudogene 2 Neighboring gene cyclin G2 Neighboring gene cyclin I Neighboring gene uncharacterized LOC134481828 Neighboring gene uncharacterized LOC134481721 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene sosondowah ankyrin repeat domain family member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity. Li X, et al. J Biol Chem, 2009 Jun 19. PMID 19380581, Free PMC Article
    2. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. Nagata K, et al. J Biol Chem, 2004 Dec 31. PMID 15485874
    3. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling. Sudo K, et al. Hum Mutat, 2007 Oct. PMID 17546647
    4. Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Tsang CW, et al. Mol Cell Biol, 2008 Dec. PMID 18809578, Free PMC Article
    5. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, et al. Mol Cell Proteomics, 2007 May. PMID 16854843

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Electron microscopy immunocytochemistry of the cerebellum revealed the accumulation of septin 11 at the neck of dendritic spines, at the bifurcation of dendritic branches, and at some GABAergic synapses.
      Title: Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity.
    2. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
      Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
    3. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption.
      Title: Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization of symmetric synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    septin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107208.3 → NP_001100678.1  septin-11

      See identical proteins and their annotated locations for NP_001100678.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AAG9
      Related
      ENSRNOP00000090314.1, ENSRNOT00000100885.1
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      15119760..15275222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091849.2 → XP_038947777.1  septin-11 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNQ9, A0A8I6AAG9
      Related
      ENSRNOP00000078633.1
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    2. XM_039091850.2 → XP_038947778.1  septin-11 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AAG9
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    3. XM_039091848.2 → XP_038947776.1  septin-11 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAG9, A0A8L2QUR1
      Related
      ENSRNOP00000062626.2
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    4. XM_039091846.2 → XP_038947774.1  septin-11 isoform X2

      UniProtKB/Swiss-Prot
      B3DMA8, B3GNI4, B3GNI6
      UniProtKB/TrEMBL
      A0A8I6AAG9
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    5. XM_039091843.2 → XP_038947771.1  septin-11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAG9
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    6. XM_039091845.2 → XP_038947773.1  septin-11 isoform X2

      UniProtKB/Swiss-Prot
      B3DMA8, B3GNI4, B3GNI6
      UniProtKB/TrEMBL
      A0A8I6AAG9
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    7. XM_039091844.2 → XP_038947772.1  septin-11 isoform X2

      UniProtKB/Swiss-Prot
      B3DMA8, B3GNI4, B3GNI6
      UniProtKB/TrEMBL
      A0A8I6AAG9
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    8. XM_039091842.2 → XP_038947770.1  septin-11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAG9
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    9. XM_039091847.2 → XP_038947775.1  septin-11 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JUL7, A0A8I6AAG9, A6KK55
      Related
      ENSRNOP00000069146.1
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    RNA

    1. XR_005492931.2 RNA Sequence

    2. XR_005492933.2 RNA Sequence

    3. XR_005492932.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3GNI6.1 GenPept UniProtKB/Swiss-Prot:B3GNI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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