Senp8 SUMO peptidase family member, NEDD8 specific [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Senp8provided by RGD
Official Full Name: SUMO peptidase family member, NEDD8 specificprovided by RGD
Primary source: RGD:1309955
See related: Ensembl:ENSRNOG00000011595 AllianceGenome:RGD:1309955
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cysteine-type peptidase activity. Predicted to be involved in protein desumoylation. Predicted to be active in nucleus. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 66.3), Muscle (RPKM 63.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (69031230..69044616, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (60135446..60148836, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (64558994..64572850, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deneddylating enzyme SENP8 regulates neuronal development.
Title: Deneddylating enzyme SENP8 regulates neuronal development.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deNEDDylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein deneddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sentrin-specific protease 8

Names: NEDD8-specific protease 1; SUMO/sentrin peptidase family member, NEDD8 specific; SUMO/sentrin specific peptidase 8; SUMO/sentrin specific peptidase family member 8; SUMO/sentrin specific protease family member 8; Sumo1/sentrin/SMT3 specific peptidase 8; deneddylase-1; sentrin/SUMO-specific protease SENP8

NP_001012355.1

EC 3.4.22.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012355.1 → NP_001012355.1 sentrin-specific protease 8

See identical proteins and their annotated locations for NP_001012355.1

Status: PROVISIONAL

Source sequence(s)

BC089939

UniProtKB/Swiss-Prot

Q5FVJ8

UniProtKB/TrEMBL

A6J539

Related

ENSRNOP00000086922.1, ENSRNOT00000111287.1

Conserved Domains (1) summary

COG5160
Location:17 → 172

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]