MET10 sulfite reductase subunit alpha [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MET10
Gene description: sulfite reductase subunit alpha
Primary source: FungiDB:YFR030W
Locus tag: YFR030W
See related: SGD:S000001926; AllianceGenome:SGD:S000001926; VEuPathDB:YFR030W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to sulfite reductase (NADPH) activity. Involved in sulfate assimilation. Part of sulfite reductase complex (NADPH). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MET10 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (213312..216419)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thus, a compromised MsrA function combined with alpha-synuclein overexpression may promote processes leading to synucleinopathies.
Title: Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.
Specific mutations in the MET10 and MET5 genes, which encode the catalytic alpha- and beta-subunits of the sulfite reductase enzyme, respectively, were identified in strains producing decreased amount of H2S.
Title: Isolation of sulfite reductase variants of a commercial wine yeast with significantly reduced hydrogen sulfide production.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
contributes_to sulfite reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfite reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hydrogen sulfide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sulfate assimilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of sulfite reductase complex (NADPH)	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sulfite reductase subunit alpha

NP_116686.3

EC 1.8.1.2

Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

213312..216419

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179995.3 → NP_116686.3 TPA: sulfite reductase subunit alpha [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116686.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTR0, P39692, Q12683

UniProtKB/TrEMBL

A0A023VTQ0, A0A8H8ULB2, A7A267, B5VI55, N1PA31

Conserved Domains (2) summary

cd06207
Location:654 → 1035

CyPoR_like; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...

COG0674
Location:1 → 334

PorA; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit [Energy production and conversion]