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    Uspl1 ubiquitin specific peptidase like 1 [ Mus musculus (house mouse) ]

    Gene ID: 231915, updated on 25-May-2024

    Summary

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    Official Symbol
    Uspl1provided by MGI
    Official Full Name
    ubiquitin specific peptidase like 1provided by MGI
    Primary source
    MGI:MGI:2442342
    See related
    Ensembl:ENSMUSG00000041264 AllianceGenome:MGI:2442342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430026A01Rik
    Summary
    Predicted to enable SUMO binding activity and SUMO-specific isopeptidase activity. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be active in Cajal body. Is expressed in several structures, including early conceptus; metanephros; secondary oocyte; skeletal muscle; and spinal cord. Orthologous to human USPL1 (ubiquitin specific peptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.4), thymus adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uspl1 in Genome Data Viewer
    Location:
    5 G3; 5 89.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (149121338..149152246)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (149184560..149215434)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene macrophage M2 polarization regulator Neighboring gene predicted gene 42788 Neighboring gene glucosamine-6-phosphate deaminase 1 pseudogene Neighboring gene RIKEN cDNA 2310047D07 gene Neighboring gene STARR-seq mESC enhancer starr_14930 Neighboring gene nuclear encoded tRNA asparagine 14 (anticodon GTT) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:150057677-150057931 Neighboring gene predicted gene, 24105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neurodevelopmental consequences of Smn depletion in a mouse model of spinal muscular atrophy. Liu H, et al. J Neurosci Res, 2010 Jan. PMID 19642194
    2. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. Bäumer D, et al. PLoS Genet, 2009 Dec. PMID 20019802, Free PMC Article
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • D030048C09

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deSUMOylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cajal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Cajal body organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-specific isopeptidase USPL1
    Names
    ubiquitin-specific peptidase-like protein 1
    NP_001013396.2
    NP_001108621.1
    NP_001108622.1
    NP_001108623.1
    NP_001108625.1
    NP_001273753.1
    NP_001273754.1
    NP_001346885.1
    NP_001346886.1
    XP_036020999.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013378.2 → NP_001013396.2  SUMO-specific isopeptidase USPL1 isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains alternate splice sites in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform C, which is shorter and has a distinct C-terminus, compared to isoform A. Variants 4 and 9 both encode the same isoform (C).
      Source sequence(s)
      AK168702, BC086664, BY203045
      Consensus CDS
      CCDS39406.1
      UniProtKB/Swiss-Prot
      Q3ULM6
      Related
      ENSMUSP00000097978.4, ENSMUST00000100410.10
      Conserved Domains (1) summary
      pfam15499
      Location:216 → 486
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    2. NM_001115149.1 → NP_001108621.1  SUMO-specific isopeptidase USPL1 isoform A

      See identical proteins and their annotated locations for NP_001108621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (A).
      Source sequence(s)
      AK050969, AK168702, BC086664, BY203045
      Consensus CDS
      CCDS51704.1
      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      E9QLC6
      Related
      ENSMUSP00000050172.10, ENSMUST00000050472.16
      Conserved Domains (2) summary
      pfam15499
      Location:216 → 486
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:558 → 1087
      DUF4650; Domain of unknown function (DUF4650)

    3. NM_001115150.1 → NP_001108622.1  SUMO-specific isopeptidase USPL1 isoform B

      See identical proteins and their annotated locations for NP_001108622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 7, and 8 all encode the same isoform (B) which is shorter at the N-terminus, compared to isoform A.
      Source sequence(s)
      AK161654, AK168702, AK168981, BC086664, BY203045
      Consensus CDS
      CCDS51706.1
      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      A0A0R4J1P9
      Related
      ENSMUSP00000113894.2, ENSMUST00000121416.8
      Conserved Domains (2) summary
      pfam15499
      Location:15 → 287
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:359 → 888
      DUF4650; Domain of unknown function (DUF4650)

    4. NM_001115151.1 → NP_001108623.1  SUMO-specific isopeptidase USPL1 isoform D

      See identical proteins and their annotated locations for NP_001108623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, uses alternate splice sites in the 3' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform D, which is shorter and has a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AK146820, AK161654, BC086664, BY203045
      Consensus CDS
      CCDS51705.1
      UniProtKB/Swiss-Prot
      Q3ULM6
      Related
      ENSMUSP00000113176.2, ENSMUST00000117878.8
      Conserved Domains (1) summary
      pfam15499
      Location:17 → 287
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    5. NM_001115153.1 → NP_001108625.1  SUMO-specific isopeptidase USPL1 isoform A

      See identical proteins and their annotated locations for NP_001108625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A). Variants 1 and 2 both encode the same isoform (A).
      Source sequence(s)
      AK145409, AK161654, AK168981, BC086664, BY203045
      Consensus CDS
      CCDS51704.1
      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      E9QLC6
      Related
      ENSMUSP00000113247.2, ENSMUST00000122160.8
      Conserved Domains (2) summary
      pfam15499
      Location:216 → 486
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:558 → 1087
      DUF4650; Domain of unknown function (DUF4650)

    6. NM_001286824.1 → NP_001273753.1  SUMO-specific isopeptidase USPL1 isoform E

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform E, which is shorter than isoform A.
      Source sequence(s)
      AK168702, AK168981, BC086664, BY203045
      Consensus CDS
      CCDS71718.1
      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      D3YW34
      Related
      ENSMUSP00000114104.2, ENSMUST00000119685.8
      Conserved Domains (2) summary
      pfam15499
      Location:202 → 472
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:544 → 1073
      DUF4650; Domain of unknown function (DUF4650)

    7. NM_001286825.1 → NP_001273754.1  SUMO-specific isopeptidase USPL1 isoform B

      See identical proteins and their annotated locations for NP_001273754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 7, and 8 all encode the same isoform (B) which is shorter at the N-terminus, compared to isoform A.
      Source sequence(s)
      AK145409, AK168702, BC086664, BY203045
      Consensus CDS
      CCDS51706.1
      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      A0A0R4J1P9
      Conserved Domains (2) summary
      pfam15499
      Location:15 → 287
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:359 → 888
      DUF4650; Domain of unknown function (DUF4650)

    8. NM_001359956.1 → NP_001346885.1  SUMO-specific isopeptidase USPL1 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 7, and 8 all encode the same isoform (B) which is shorter at the N-terminus, compared to isoform A.
      Source sequence(s)
      AC122546
      Consensus CDS
      CCDS51706.1
      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      A0A0R4J1P9
      Conserved Domains (2) summary
      pfam15499
      Location:15 → 287
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:359 → 888
      DUF4650; Domain of unknown function (DUF4650)

    9. NM_001359957.1 → NP_001346886.1  SUMO-specific isopeptidase USPL1 isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains alternate splice sites in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform C, which is shorter and has a distinct C-terminus, compared to isoform A. Variants 4 and 9 both encode the same isoform (C).
      Source sequence(s)
      AC122546
      Consensus CDS
      CCDS39406.1
      Conserved Domains (1) summary
      pfam15499
      Location:216 → 486
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      149121338..149152246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165106.1 → XP_036020999.1  SUMO-specific isopeptidase USPL1 isoform X1

      UniProtKB/Swiss-Prot
      Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
      UniProtKB/TrEMBL
      A0A0R4J1P9
      Conserved Domains (2) summary
      pfam15499
      Location:15 → 287
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:359 → 888
      DUF4650; Domain of unknown function (DUF4650)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ULM6.2 GenPept UniProtKB/Swiss-Prot:Q3ULM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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