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    Tnni1 troponin I, skeletal, slow 1 [ Mus musculus (house mouse) ]

    Gene ID: 21952, updated on 21-May-2024

    Summary

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    Official Symbol
    Tnni1provided by MGI
    Official Full Name
    troponin I, skeletal, slow 1provided by MGI
    Primary source
    MGI:MGI:105073
    See related
    Ensembl:ENSMUSG00000026418 AllianceGenome:MGI:105073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ssTnI; 2700018B22Rik
    Summary
    Predicted to enable actin binding activity and metal ion binding activity. Acts upstream of or within transition between fast and slow fiber and ventricular cardiac muscle tissue morphogenesis. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; diaphragm; heart; nervous system; and skeletal musculature. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 75.2), colon adult (RPKM 20.1) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnni1 in Genome Data Viewer
    Location:
    1 E4; 1 59.28 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135709252..135738727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135783033..135810989)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene pleckstrin homology like domain, family A, member 3 Neighboring gene STARR-seq mESC enhancer starr_02392 Neighboring gene STARR-seq mESC enhancer starr_02394 Neighboring gene ladinin Neighboring gene troponin T2, cardiac

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNA methylation regulates mouse cardiac myofibril gene expression during heart development. Xu Y, et al. J Biomed Sci, 2015 Oct 17. PMID 26475623, Free PMC Article
    2. Functional characterization of mouse fetal TnI gene promoters in myocardial cells. Du J, et al. J Biomed Sci, 2008 Sep. PMID 18357515
    3. Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. Layland J, et al. FASEB J, 2005 Jul. PMID 15855227
    4. Thyroid hormone inhibits slow skeletal TnI expression in cardiac TnI-null myocardial cells. Riedel B, et al. Tissue Cell, 2005 Feb. PMID 15695175
    5. The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect. Hornos F, et al. J Biol Chem, 2021 Jan-Jun. PMID 33814345, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
      Title: The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
    2. the up-stream domain ( approximately 1,800 bp) of mouse fetal TnI gene is been cloned and characterized
      Title: Functional characterization of mouse fetal TnI gene promoters in myocardial cells.
    3. Phosphorylation of troponin I was significantly reduced in Galphaq-overexpressing mice compared to wild type.
      Title: Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice.
    4. data demonstrate that thyroid hormone can alter the time course of ssTnI gene expression in cultured cardiac myocytes and TnI gene regulation is also controlled by some unknown programmed events inside of cardiac myocytes
      Title: Thyroid hormone inhibits slow skeletal TnI expression in cardiac TnI-null myocardial cells.
    5. K+-depolarization increased Tnni1 and Acta1 mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture
      Title: Differential gene expression in skeletal muscle cells after membrane depolarization.
    6. a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges
      Title: Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    troponin I, slow skeletal muscle

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112702.1 → NP_001106173.1  troponin I, slow skeletal muscle

      See identical proteins and their annotated locations for NP_001106173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA271187, AK012258, AV124377, CR521220
      Consensus CDS
      CCDS48374.1
      UniProtKB/Swiss-Prot
      Q9WUZ5
      UniProtKB/TrEMBL
      F6QC77
      Related
      ENSMUSP00000122925.2, ENSMUST00000154463.8
      Conserved Domains (1) summary
      pfam00992
      Location:15 → 146
      Troponin

    2. NM_021467.5 → NP_067442.1  troponin I, slow skeletal muscle

      See identical proteins and their annotated locations for NP_067442.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA230582, AK012258, AV124377, CR521220
      Consensus CDS
      CCDS48374.1
      UniProtKB/Swiss-Prot
      Q9WUZ5
      UniProtKB/TrEMBL
      F6QC77
      Related
      ENSMUSP00000121966.2, ENSMUST00000152208.8
      Conserved Domains (1) summary
      pfam00992
      Location:15 → 146
      Troponin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135709252..135738727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163551.1 → XP_036019444.1  troponin I, slow skeletal muscle isoform X1

      UniProtKB/Swiss-Prot
      Q9WUZ5
      UniProtKB/TrEMBL
      F6QC77
      Conserved Domains (1) summary
      pfam00992
      Location:15 → 146
      Troponin

    2. XM_011247974.4 → XP_011246276.1  troponin I, slow skeletal muscle isoform X1

      See identical proteins and their annotated locations for XP_011246276.1

      UniProtKB/Swiss-Prot
      Q9WUZ5
      UniProtKB/TrEMBL
      F6QC77
      Conserved Domains (1) summary
      pfam00992
      Location:15 → 146
      Troponin

    3. XM_006529382.4 → XP_006529445.1  troponin I, slow skeletal muscle isoform X1

      See identical proteins and their annotated locations for XP_006529445.1

      UniProtKB/Swiss-Prot
      Q9WUZ5
      UniProtKB/TrEMBL
      F6QC77
      Conserved Domains (1) summary
      pfam00992
      Location:15 → 146
      Troponin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUZ5.3 GenPept UniProtKB/Swiss-Prot:Q9WUZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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