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    Cnfn cornifelin [ Mus musculus (house mouse) ]

    Gene ID: 72383, updated on 5-Mar-2024

    Summary

    Official Symbol
    Cnfnprovided by MGI
    Official Full Name
    cornifelinprovided by MGI
    Primary source
    MGI:MGI:1919633
    See related
    Ensembl:ENSMUSG00000063651 AllianceGenome:MGI:1919633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210418J09Rik
    Summary
    Predicted to act upstream of or within keratinization. Predicted to be located in cytoplasm. Predicted to be active in cornified envelope. Is expressed in external naris. Orthologous to human CNFN (cornifelin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward stomach adult (RPKM 1304.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cnfn in Genome Data Viewer
    Location:
    7 A3; 7 13.78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25067041..25069149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25367616..25369724, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 145 Neighboring gene multiple EGF-like-domains 8 Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene STARR-positive B cell enhancer ABC_E2227 Neighboring gene STARR-positive B cell enhancer ABC_E11345 Neighboring gene lipase, hormone sensitive Neighboring gene C-X-C motif chemokine ligand 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cornified envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081375.1NP_001074844.1  cornifelin isoform 2

      See identical proteins and their annotated locations for NP_001074844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC156992
      Consensus CDS
      CCDS39838.1
      UniProtKB/Swiss-Prot
      Q6PCW6
      Related
      ENSMUSP00000075625.4, ENSMUST00000076276.5
      Conserved Domains (1) summary
      TIGR01571
      Location:21109
      A_thal_Cys_rich; uncharacterized Cys-rich domain
    2. NM_028219.1NP_082495.1  cornifelin isoform 1

      See identical proteins and their annotated locations for NP_082495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC156992
      Consensus CDS
      CCDS52149.1
      UniProtKB/TrEMBL
      G3UWC9
      Related
      ENSMUSP00000130957.2, ENSMUST00000167591.8
      Conserved Domains (1) summary
      TIGR01571
      Location:34122
      A_thal_Cys_rich; uncharacterized Cys-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25067041..25069149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)