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    Ube2j2 ubiquitin-conjugating enzyme E2, J2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298689, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ube2j2provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2, J2provided by RGD
    Primary source
    RGD:1359523
    See related
    Ensembl:ENSRNOG00000019749 AllianceGenome:RGD:1359523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of protein targeting to mitochondrion; protein polyubiquitination; and ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum and nucleus. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 159.3), Thymus (RPKM 155.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2j2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171815607..171830037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166533374..166547811)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173372659..173387084)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel epithelial 1 delta subunit Neighboring gene C1q and TNF related 12 Neighboring gene uncharacterized LOC134487051 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). Tiwari S, et al. J Biol Chem, 2001 May 11. PMID 11278356
    2. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. van de Weijer ML, et al. Nat Commun, 2014 May 8. PMID 24807418, Free PMC Article
    3. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). El Khouri E, et al. J Biol Chem, 2013 Oct 25. PMID 24019521, Free PMC Article
    4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. David Y, et al. J Biol Chem, 2010 Mar 19. PMID 20061386, Free PMC Article
    5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94113

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 J2
    Names
    ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
    NP_001007656.2
    XP_006239616.1
    XP_006239617.1
    XP_006239619.1
    XP_006239620.1
    XP_008762577.1
    XP_063143577.1
    XP_063143578.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007655.2 → NP_001007656.2  ubiquitin-conjugating enzyme E2 J2

      See identical proteins and their annotated locations for NP_001007656.2

      Status: VALIDATED

      Source sequence(s)
      BC079115, JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
      Conserved Domains (1) summary
      cd00195
      Location:26 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171815607..171830037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287508.1 → XP_063143578.1  ubiquitin-conjugating enzyme E2 J2 isoform X3

    2. XM_006239558.5 → XP_006239620.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

      See identical proteins and their annotated locations for XP_006239620.1

      UniProtKB/TrEMBL
      A0A8J8XLZ8, G3V8L8, Q6AYB7
      Conserved Domains (1) summary
      cd00195
      Location:14 → 127
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. XM_063287507.1 → XP_063143577.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C5, A6IUU4

    4. XM_006239555.5 → XP_006239617.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

      See identical proteins and their annotated locations for XP_006239617.1

      UniProtKB/TrEMBL
      A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
      Related
      ENSRNOP00000074553.1
      Conserved Domains (1) summary
      cd00195
      Location:26 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. XM_006239557.5 → XP_006239619.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

      See identical proteins and their annotated locations for XP_006239619.1

      UniProtKB/TrEMBL
      A0A8J8XLZ8, G3V8L8, Q6AYB7
      Conserved Domains (1) summary
      cd00195
      Location:14 → 127
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    6. XM_006239554.5 → XP_006239616.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

      See identical proteins and their annotated locations for XP_006239616.1

      UniProtKB/TrEMBL
      A0A0G2K8C5, A0A8J8XLZ8, A6IUU4
      Conserved Domains (1) summary
      cd00195
      Location:26 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    7. XM_008764355.4 → XP_008762577.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

      See identical proteins and their annotated locations for XP_008762577.1

      UniProtKB/TrEMBL
      A0A8J8XLZ8, G3V8L8, Q6AYB7
      Related
      ENSRNOP00000026752.7
      Conserved Domains (1) summary
      cd00195
      Location:14 → 127
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version

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