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    SQSTM1 sequestosome 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705481, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SQSTM1provided by VGNC
    Official Full Name
    sequestosome 1provided by VGNC
    Primary source
    VGNC:VGNC:77876
    See related
    Ensembl:ENSMMUG00000021055
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SQSTM1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (177217017..177254911)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (178466647..178504877)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106999063 Neighboring gene leukotriene C4 synthase Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene MRN complex interacting protein Neighboring gene TBC1 domain family member 9B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggrephagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in amphisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sequestosome-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266358.1 → NP_001253287.1  sequestosome-1

      See identical proteins and their annotated locations for NP_001253287.1

      Status: PROVISIONAL

      Source sequence(s)
      JV048597
      UniProtKB/TrEMBL
      A0A5K1UYE4, H9G1C8
      Related
      ENSMMUP00000033598.3, ENSMMUT00000040542.3
      Conserved Domains (3) summary
      cd06402
      Location:4 → 102
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:126 → 168
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl21463
      Location:378 → 438
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      177217017..177254911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141574.2 → XP_014997060.2  sequestosome-1 isoform X2

      UniProtKB/TrEMBL
      F7GSB8, F7H1Y2, H9ZEV6
      Conserved Domains (3) summary
      cd02340
      Location:42 → 84
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl02720
      Location:1 → 18
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
      pfam16577
      Location:295 → 356
      UBA_5; UBA domain

    2. XM_015141573.2 → XP_014997059.2  sequestosome-1 isoform X2

      UniProtKB/TrEMBL
      F7GSB8, F7H1Y2, H9ZEV6
      Conserved Domains (3) summary
      cd02340
      Location:42 → 84
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl02720
      Location:1 → 18
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
      pfam16577
      Location:295 → 356
      UBA_5; UBA domain

    3. XM_015141572.2 → XP_014997058.2  sequestosome-1 isoform X2

      UniProtKB/TrEMBL
      F7GSB8, F7H1Y2, H9ZEV6
      Conserved Domains (3) summary
      cd02340
      Location:42 → 84
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl02720
      Location:1 → 18
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
      pfam16577
      Location:295 → 356
      UBA_5; UBA domain

    4. XM_028849196.1 → XP_028705029.1  sequestosome-1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8ASX3, F7GSB8, F7H1Y2, H9ZEV6
      Related
      ENSMMUP00000080922.1, ENSMMUT00000089903.1
      Conserved Domains (3) summary
      cd06402
      Location:4 → 102
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:126 → 168
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      pfam16577
      Location:352 → 413
      UBA_5; UBA domain
    Nucleotide Protein
    Heading Accession and Version

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