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    Prss35 serine protease 35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315866, updated on 13-Apr-2024

    Summary

    Official Symbol
    Prss35provided by RGD
    Official Full Name
    serine protease 35provided by RGD
    Primary source
    RGD:1311282
    See related
    Ensembl:ENSRNOG00000025184 AllianceGenome:RGD:1311282
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS35 (serine protease 35). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 43.9), Testes (RPKM 27.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Prss35 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96594460..96610992)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (87714449..87731009)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94423629..94440509)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene malic enzyme 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene synaptosome associated protein 91 Neighboring gene ripply transcriptional repressor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inactive serine protease 35
    Names
    protease, serine, 35

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008560.2NP_001008560.2  inactive serine protease 35 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5R212
      UniProtKB/TrEMBL
      A6I1V5, F1LLW4
      Related
      ENSRNOP00000036136.4, ENSRNOT00000034683.5
      Conserved Domains (1) summary
      cl21584
      Location:138174
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      96594460..96610992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595670.3XP_017451159.1  inactive serine protease 35 isoform X1

      UniProtKB/Swiss-Prot
      Q5R212
      UniProtKB/TrEMBL
      A6I1V5, F1LLW4
      Conserved Domains (1) summary
      cl21584
      Location:138174
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...