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    Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67763, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Prpsap1provided by MGI
    Official Full Name
    phosphoribosyl pyrophosphate synthetase-associated protein 1provided by MGI
    Primary source
    MGI:MGI:1915013
    See related
    Ensembl:ENSMUSG00000015869 AllianceGenome:MGI:1915013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAP39; 5730409F23Rik
    Summary
    Predicted to enable several functions, including identical protein binding activity; kinase binding activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process; negative regulation of kinase activity; and purine nucleotide biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 235.5), small intestine adult (RPKM 111.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prpsap1 in Genome Data Viewer
    Location:
    11 E2; 11 81.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116361641..116385739, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116470816..116494913, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2 Neighboring gene STARR-positive B cell enhancer ABC_E7101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116351868-116352051 Neighboring gene ribosomal protein L36, pseudogene 1 Neighboring gene sphingosine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. De Cegli R, et al. Nucleic Acids Res, 2013 Jan. PMID 23180766, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose phosphate diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribose phosphate diphosphokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribose phosphate diphosphokinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphoribosyl pyrophosphate synthase-associated protein 1
    Names
    39 kDa phosphoribosypyrophosphate synthase-associated protein
    39 kDa phosphoribosypyrophosphate synthetase-associated protein
    PRPP synthase-associated protein 1
    PRPP synthetase-associated protein 1
    NP_001391595.1
    NP_001391596.1
    NP_001391597.1
    NP_001391598.1
    NP_080640.1
    XP_011247498.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404666.1 → NP_001391595.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645851
      UniProtKB/Swiss-Prot
      Q9D0M1

    2. NM_001404667.1 → NP_001391596.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645851
      UniProtKB/Swiss-Prot
      Q9D0M1

    3. NM_001404668.1 → NP_001391597.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645851
      UniProtKB/Swiss-Prot
      Q9D0M1

    4. NM_001404669.1 → NP_001391598.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645851
      UniProtKB/Swiss-Prot
      Q9D0M1
      UniProtKB/TrEMBL
      B1AT84
      Related
      ENSMUSP00000115982.3, ENSMUST00000152496.9

    5. NM_026364.2 → NP_080640.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 3

      See identical proteins and their annotated locations for NP_080640.1

      Status: VALIDATED

      Source sequence(s)
      AL645851
      Consensus CDS
      CCDS48985.1
      UniProtKB/Swiss-Prot
      Q9D0M1
      UniProtKB/TrEMBL
      B1AT82
      Related
      ENSMUSP00000101999.2, ENSMUST00000106391.8
      Conserved Domains (2) summary
      pfam13793
      Location:38 → 155
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:196 → 379
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116361641..116385739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249196.3 → XP_011247498.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9D0M1
      Conserved Domains (2) summary
      pfam14572
      Location:165 → 348
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain
      pfam13793
      Location:20 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0M1.1 GenPept UniProtKB/Swiss-Prot:Q9D0M1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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