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    Tmem205 transmembrane protein 205 [ Mus musculus (house mouse) ]

    Gene ID: 235043, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem205provided by MGI
    Official Full Name
    transmembrane protein 205provided by MGI
    Primary source
    MGI:MGI:3045495
    See related
    Ensembl:ENSMUSG00000040883 AllianceGenome:MGI:3045495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMEM205 (transmembrane protein 205). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 421.3), adrenal adult (RPKM 350.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem205 in Genome Data Viewer
    Location:
    9 A3; 9 7.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21832305..21838831, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21921009..21927535, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin-like 8 Neighboring gene STARR-seq mESC enhancer starr_23526 Neighboring gene STARR-seq mESC enhancer starr_23527 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene coiled-coil domain containing 159 Neighboring gene phospholipid phosphatase related 2 Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
    2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18837

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 205

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253867.1 → NP_001240796.1  transmembrane protein 205 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AI573565, BY790291, CD775257, CN840781
      Conserved Domains (1) summary
      pfam13664
      Location:73 → 172
      DUF4149; Domain of unknown function (DUF4149)

    2. NM_001253868.1 → NP_001240797.1  transmembrane protein 205 isoform 2

      See identical proteins and their annotated locations for NP_001240797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
      Source sequence(s)
      AI573565, BY790291, CD775257
      Consensus CDS
      CCDS22913.1
      UniProtKB/Swiss-Prot
      Q91XE8, Q9JME6
      UniProtKB/TrEMBL
      A0A1L1SSA8
      Related
      ENSMUSP00000158874.2, ENSMUST00000238930.2
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 116
      DUF4149; Domain of unknown function (DUF4149)

    3. NM_001253869.1 → NP_001240798.1  transmembrane protein 205 isoform 2

      See identical proteins and their annotated locations for NP_001240798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a different segment for its 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
      Source sequence(s)
      CA326029, CD775257
      Consensus CDS
      CCDS22913.1
      UniProtKB/Swiss-Prot
      Q91XE8, Q9JME6
      UniProtKB/TrEMBL
      A0A1L1SSA8
      Related
      ENSMUSP00000150045.2, ENSMUST00000213698.2
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 116
      DUF4149; Domain of unknown function (DUF4149)

    4. NM_001253870.1 → NP_001240799.1  transmembrane protein 205 isoform 2

      See identical proteins and their annotated locations for NP_001240799.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two different splice sites in the 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
      Source sequence(s)
      BY790291, CD775257
      Consensus CDS
      CCDS22913.1
      UniProtKB/Swiss-Prot
      Q91XE8, Q9JME6
      UniProtKB/TrEMBL
      A0A1L1SSA8
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 116
      DUF4149; Domain of unknown function (DUF4149)

    5. NM_178577.5 → NP_848692.2  transmembrane protein 205 isoform 2

      See identical proteins and their annotated locations for NP_848692.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
      Source sequence(s)
      BY790291, CD775257
      Consensus CDS
      CCDS22913.1
      UniProtKB/Swiss-Prot
      Q91XE8, Q9JME6
      UniProtKB/TrEMBL
      A0A1L1SSA8
      Related
      ENSMUSP00000048832.10, ENSMUST00000046831.11
      Conserved Domains (1) summary
      pfam13664
      Location:17 → 116
      DUF4149; Domain of unknown function (DUF4149)

    RNA

    1. NR_045606.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses a different splice site in the 5' end and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because translation from the larger, downstream ORF mades the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC166992, BY790291, CD775257

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21832305..21838831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XE8.1 GenPept UniProtKB/Swiss-Prot:Q91XE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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