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    Hmgxb4 HMG-box containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307667, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Hmgxb4provided by RGD
    Official Full Name
    HMG-box containing 4provided by RGD
    Primary source
    RGD:1305783
    See related
    Ensembl:ENSRNOG00000013878 AllianceGenome:RGD:1305783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hmg2l1; Hmgb2l1
    Summary
    Predicted to enable identical protein binding activity. Predicted to be part of NURF complex. Orthologous to human HMGXB4 (HMG-box containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 48.6), Lung (RPKM 38.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hmgxb4 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (13370559..13409306)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (13364741..13403563)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (14352644..14390499)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694287 Neighboring gene ribosomal protein S2, pseudogene 41 Neighboring gene uncharacterized LOC102556139 Neighboring gene target of myb1 membrane trafficking protein Neighboring gene uncharacterized LOC134483111 Neighboring gene heme oxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1. Zhou J, et al. J Biol Chem, 2010 Jul 23. PMID 20511232, Free PMC Article
    2. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Vermeulen M, et al. Cell, 2010 Sep 17. PMID 20850016

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the first evidence of this novel HMG2L1 molecule playing an important role in attenuating smooth muscle differentiation
      Title: Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HMG domain-containing protein 4
    Names
    HMG box domain containing 4
    high mobility group box 2-like 1
    high-mobility group protein 2-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415029.1 → NP_001401958.1  HMG domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    2. NM_001415030.1 → NP_001401959.1  HMG domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    3. NM_001415031.1 → NP_001401960.1  HMG domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    4. NM_001415032.1 → NP_001401961.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6JY93, D4A2N0
      Related
      ENSRNOP00000061759.2, ENSRNOT00000067519.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      13370559..13409306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278001.1 → XP_063134071.1  HMG domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y143, A6JY93

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107412.1: Suppressed sequence

      Description
      NM_001107412.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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