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    Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289400, updated on 2-May-2024

    Summary

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    Official Symbol
    Camsap2provided by RGD
    Official Full Name
    calmodulin regulated spectrin-associated protein family, member 2provided by RGD
    Primary source
    RGD:1310950
    See related
    Ensembl:ENSRNOG00000008741 AllianceGenome:RGD:1310950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Camsap1l1; RGD1310950
    Summary
    Predicted to enable microtubule minus-end binding activity. Involved in axon development and regulation of dendrite development. Predicted to be located in ciliary basal body; cytosol; and microtubule end. Predicted to colocalize with Golgi apparatus; centrosome; and microtubule minus-end. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 292.1), Lung (RPKM 162.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camsap2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50274950..50354298, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47723251..47802606, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53145712..53225349, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096220 Neighboring gene innate immunity activator Neighboring gene G protein-coupled receptor 25 Neighboring gene uncharacterized LOC134481565 Neighboring gene ribosomal protein L31 like 9 Neighboring gene uncharacterized LOC102547307 Neighboring gene DEAD-box helicase 59

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization. Mao BP, et al. Endocrinology, 2019 Jun 1. PMID 30994903, Free PMC Article
    2. Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development. Yau KW, et al. Neuron, 2014 Jun 4. PMID 24908486
    3. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Wu J, et al. Dev Cell, 2016 Oct 10. PMID 27666745
    4. Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules. Tanaka N, et al. Proc Natl Acad Sci U S A, 2012 Dec 4. PMID 23169647, Free PMC Article
    5. Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Jiang K, et al. Dev Cell, 2014 Feb 10. PMID 24486153

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In summary, CAMSAP2 is a regulator of microtubule and actin dynamics in Sertoli cells to support blood-testis barrier dynamics and spermatogenesis.
      Title: CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spectrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of organelle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule end ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule minus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule minus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule minus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-regulated spectrin-associated protein 2
    Names
    calmodulin regulated spectrin-associated protein 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134503.2 → NP_001127975.1  calmodulin-regulated spectrin-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001127975.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      A0A0G2K7K9, D4AEC2
      UniProtKB/TrEMBL
      A0A8I6A5G7
      Related
      ENSRNOP00000057155.2, ENSRNOT00000060410.5
      Conserved Domains (4) summary
      pfam08683
      Location:1331 → 1449
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:237 → 315
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:737 → 787
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl26464
      Location:915 → 1028
      Atrophin-1; Atrophin-1 family

    2. NM_001415803.1 → NP_001402732.1  calmodulin-regulated spectrin-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      Related
      ENSRNOP00000088623.1, ENSRNOT00000098757.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      50274950..50354298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272200.1 → XP_063128270.1  calmodulin-regulated spectrin-associated protein 2 isoform X5

    2. XM_039090610.2 → XP_038946538.1  calmodulin-regulated spectrin-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A5H1ZRV8, A0A8I6A5G7
      Related
      ENSRNOP00000074249.2
      Conserved Domains (4) summary
      PHA03247
      Location:904 → 1017
      PHA03247; large tegument protein UL36; Provisional
      pfam11971
      Location:226 → 304
      CAMSAP_CH; CAMSAP CH domain
      pfam08683
      Location:1329 → 1447
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam17095
      Location:726 → 776
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    3. XM_063272199.1 → XP_063128269.1  calmodulin-regulated spectrin-associated protein 2 isoform X4

    4. XM_039090612.2 → XP_038946540.1  calmodulin-regulated spectrin-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5G7
      Conserved Domains (4) summary
      PHA03247
      Location:915 → 1028
      PHA03247; large tegument protein UL36; Provisional
      pfam11971
      Location:237 → 315
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:737 → 787
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl07883
      Location:1340 → 1400
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

    5. XM_039090609.2 → XP_038946537.1  calmodulin-regulated spectrin-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5G7
      Conserved Domains (4) summary
      PHA03247
      Location:915 → 1028
      PHA03247; large tegument protein UL36; Provisional
      pfam11971
      Location:237 → 315
      CAMSAP_CH; CAMSAP CH domain
      pfam08683
      Location:1340 → 1458
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam17095
      Location:737 → 787
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AEC2.1 GenPept UniProtKB/Swiss-Prot:D4AEC2

    Gene LinkOut

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