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    Ces5a carboxylesterase 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307660, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ces5aprovided by RGD
    Official Full Name
    carboxylesterase 5Aprovided by RGD
    Primary source
    RGD:1549717
    See related
    Ensembl:ENSRNOG00000025710 AllianceGenome:RGD:1549717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ces5; Ces7
    Summary
    Predicted to enable methyl indole-3-acetate esterase activity. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Orthologous to human CES5A (carboxylesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 15.6) and Brain (RPKM 3.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ces5a in Genome Data Viewer
    Location:
    19p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (11198829..11504887)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (11469431..11499007)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (12097529..12136579)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483691 Neighboring gene autocrine motility factor receptor Neighboring gene G protein subunit alpha o1 Neighboring gene uncharacterized LOC120098573 Neighboring gene uncharacterized LOC134483693 Neighboring gene uncharacterized LOC134483695 Neighboring gene uncharacterized LOC134483692 Neighboring gene LARGE xylosyl- and glucuronyltransferase 1 Neighboring gene uncharacterized LOC134483690

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat. Ru YF, et al. Asian J Androl, 2015 Mar-Apr. PMID 25475668, Free PMC Article
    2. Identification and characterization of an epididymis-specific gene, Ces7. Zhang L, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Oct. PMID 19779645
    3. Baculo-expression and enzymatic characterization of CES7 esterase. Zhang L, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Sep. PMID 19727521
    4. Mammalian carboxylesterase 5: comparative biochemistry and genomics. Holmes RS, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2008 Sep. PMID 19727319, Free PMC Article
    5. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CES5A plays an important role in sperm maturation and male fertility in the rat.
      Title: An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 5A
    Names
    carboxylesterase 615
    carboxylesterase 7
    carboxylesterase-like urinary excreted protein homolog
    cauxin
    epididymis-specific gene 615 protein
    NP_001012056.2
    XP_063134066.1
    XP_063134067.1
    XP_063134068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012056.2 → NP_001012056.2  carboxylesterase 5A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5GRG2
      UniProtKB/TrEMBL
      F1M786
      Related
      ENSRNOP00000045129.5, ENSRNOT00000049452.5
      Conserved Domains (1) summary
      cd00312
      Location:40 → 529
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      11198829..11504887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277997.1 → XP_063134067.1  carboxylesterase 5A isoform X2

    2. XM_063277996.1 → XP_063134066.1  carboxylesterase 5A isoform X1

      UniProtKB/Swiss-Prot
      Q5GRG2

    3. XM_063277998.1 → XP_063134068.1  carboxylesterase 5A isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GRG2.1 GenPept UniProtKB/Swiss-Prot:Q5GRG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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