Mc4r melanocortin 4 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mc4rprovided by RGD
Official Full Name: melanocortin 4 receptorprovided by RGD
Primary source: RGD:3057
See related: Ensembl:ENSRNOG00000018692 AllianceGenome:RGD:3057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables melanocortin receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Located in nucleus and plasma membrane. Used to study obesity. Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (62689798..62691685, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (60419832..60421719, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (62612838..62614725, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception.
Title: Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception.
Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.
Title: Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.
Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage and Mitochondrial Dysfunction in Cultured Hippocampal Neurons Exposed to Ethanol.
Title: Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage and Mitochondrial Dysfunction in Cultured Hippocampal Neurons Exposed to Ethanol.
The increase in hypothalamic nesfatin-1 participates in regulating feeding behavior through the MC3/4R-ERK signaling especially after SG and RYGB.
Title: Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK signaling pathway after weight loss in obese Sprague-Dawley rats.
deficiency was associated with impaired ventilatory responses to hypercapnia independently of obesity
Title: Role of melanocortin 4 receptor in hypertension induced by chronic intermittent hypoxia.
findings suggest that alpha-MSH suppresses I A by activating MC4R, which is coupled sequentially to the Gbetagamma complex of the Gi/o-protein and downstream class I PI3K-dependent p38alpha signaling, thereby increasing TG neuronal excitability and mechanical pain sensitivity in rats.
Title: Melanocortin type 4 receptor-mediated inhibition of A-type K(+) current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.
MC3R deficiency caused a reduction of food intake and body weight, whereas at the same time exhibited additive effects on top of MC4R deficiency on lipid and glucose metabolism.
Title: Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.
Thus study demonstrated that Adolescent Alcohol Exposure-Induced Changes in melanocortin 4 receptor.
Title: Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood.
results revealed that MC4R activation was able to attenuate oxidative stress and mitochondrial dysfunction in skeletal muscle induced by diabetes partially through activating the AMPK-SIRT1-PGC-1alpha signaling pathway.
Title: Melanocortin 4 Receptor Activation Attenuates Mitochondrial Dysfunction in Skeletal Muscle of Diabetic Rats.
Although MC4R obese pregnant rats had elevated blood pressure associated with reduced total NOS activity and expression, they had enhanced NOS-mediated attenuation of vasoconstriction, with no evidence of alterations in NOS-mediated regulation of blood pressure.
Title: Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats.

Submit: New GeneRIF Correction See all GeneRIFs (63)

General gene information

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Markers

PMC314306P3 (e-PCR)
- UniSTS:272935

PMC314306P4 (e-PCR)
- UniSTS:272936

MC4R (e-PCR)
- UniSTS:266639

RH94805 (e-PCR)
- UniSTS:120051

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables melanocortin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables melanocortin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables melanocortin receptor activity	ISO Inferred from Sequence Orthology more info
enables melanocyte-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melanocyte-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in diet induced thermogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in energy reserve metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in feeding behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to bisphenol A	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to melanocyte-stimulating hormone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanocortin receptor 4

Names: MC4-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013099.3 → NP_037231.1 melanocortin receptor 4

See identical proteins and their annotated locations for NP_037231.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P70596

UniProtKB/TrEMBL

A6IXT4

Related

ENSRNOP00000025223.1, ENSRNOT00000025223.4

Conserved Domains (1) summary

cd15353
Location:45 → 313

7tmA_MC4R; melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors