Mn1 meningioma 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mn1provided by MGI
Official Full Name: meningioma 1provided by MGI
Primary source: MGI:MGI:1261813
See related: Ensembl:ENSMUSG00000070576 AllianceGenome:MGI:1261813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within intramembranous ossification. Predicted to be located in nucleus. Is expressed in several structures, including brain; limb long bone; palatal shelf; tarsus; and ventral grey horn. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 15.7), CNS E14 (RPKM 12.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (111565145..111604890)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (111417300..111457030)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.
Title: Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.
Menin is necessary for long term maintenance of meningioma-1 driven leukemia.
Title: Menin is necessary for long term maintenance of meningioma-1 driven leukemia.
Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia.
Title: Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia.
identified Meis2 as critical to MN1-induced leukemia, with essential roles in proliferation, self-renewal, impairment of differentiation and disease progression in vitro and in vivo.
Title: Meis2 as a critical player in MN1-induced leukemia.
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
Title: MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
The critical amino acid residues in the murine MN1 protein necessary for the neoplastic myeloid transformation have been identified.
Title: Mapping of MN1 sequences necessary for myeloid transformation.
Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction
Title: Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction.
Data show that genetic disruption of both FLT3 and c-Kit signaling in the MN1-leukemia model was dispensable for MN1-induced leukemogenesis.
Title: Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia.
important role for MN1 in maintaining the appropriate maturation and function of calvarial osteoblasts
Title: Meningioma 1 is required for appropriate osteoblast proliferation, motility, differentiation, and function.
Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development.
Title: The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI044850 (e-PCR)
- UniSTS:247990

NoName (e-PCR)
- UniSTS:235259

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within intramembranous ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vitamin D receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional activator MN1

Names: probable tumor suppressor protein MN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.