Plcl1 phospholipase C-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plcl1provided by RGD
Official Full Name: phospholipase C-like 1provided by RGD
Primary source: RGD:708420
See related: Ensembl:ENSRNOG00000032659 AllianceGenome:RGD:708420
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including gamma-aminobutyric acid signaling pathway; regulation of GABAergic synaptic transmission; and regulation of peptidyl-serine phosphorylation. Predicted to be located in plasma membrane. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 150.9), Kidney (RPKM 81.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (64395976..64733171)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (56901573..57238782)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (62016112..62349244)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D9Wox13 (e-PCR)
- UniSTS:518423

AU049778 (e-PCR)
- UniSTS:146224

D9Got62 (e-PCR)
- UniSTS:115261

RH132590 (e-PCR)
- UniSTS:215873

D9Mco79 (e-PCR)
- UniSTS:526177

D9Rat122 (e-PCR), detects polymorphism
- UniSTS:228325

AI072447 (e-PCR)
- UniSTS:244989

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive phospholipase C-like protein 1

Names: 130kDa-Ins(1,4,5)P3 binding protein; PLC-L1; PRIP1; p130; phospholipase C-related but catalytically inactive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053456.2 → NP_445908.2 inactive phospholipase C-like protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q62688

UniProtKB/TrEMBL

A0A0G2K4N6, A6IP21

Related

ENSRNOP00000073112.2, ENSRNOT00000090621.2

Conserved Domains (5) summary

cd00275
Location:721 → 849

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08597
Location:399 → 689

PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein

cd13364
Location:116 → 224

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd15898
Location:244 → 273

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:244 → 386

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes