Lpar1 lysophosphatidic acid receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpar1provided by RGD
Official Full Name: lysophosphatidic acid receptor 1provided by RGD
Primary source: RGD:620563
See related: Ensembl:ENSRNOG00000013656 AllianceGenome:RGD:620563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Edg2
Summary: Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; negative regulation of cAMP-mediated signaling; and nervous system development. Located in several cellular components, including dendrite; neuronal cell body; and plasma membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 71.1), Uterus (RPKM 44.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (78024139..78147071, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (73229047..73347874, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (75557038..75678067, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis.
Title: LPA(1) signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis.
The data suggest that the LPAR1 mutants perturb lysophosphatidic acid signaling in cancer tissues.
Title: Functional characterization of lysophosphatidic acid receptor 1 mutants identified in rat cancer tissues.
Lysophosphatidic acid and its receptor LPAR1, acting through the Rho-ROCK pathway, regulate P2X3 receptor in the development of both mechanical and spontaneous pain in bone cancer.
Title: Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X3 receptor-mediated bone cancer pain in rats.
Results suggest LPA signaling via activation of LPA1 may be necessary for dopamine neuron development and survival
Title: LPA signaling is required for dopaminergic neuron development and is reduced through low expression of the LPA1 receptor in a 6-OHDA lesion model of Parkinson's disease.
Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA.
Title: Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
These findings indicate lysophosphatidylethanolamine increases intracellular Ca(2+) via a LPA-1/Gi/o proteins/phospholipase C/IP3/Ca(2+) rise/Ca(2+) influx pathway in PC-12 neuronal cells.
Title: Lysophosphatidylethanolamine increases intracellular Ca(2+) through LPA(1) in PC-12 neuronal cells.
Conventional protein kinase C alpha and beta isozymes modulate LPA1 receptor phosphorylation state.
Title: Conventional protein kinase C isoforms mediate phorbol ester-induced lysophosphatidic acid LPA1 receptor phosphorylation.
The LILPA1 in dysplastic lesions and normal epithelium of Cd-treated rats was significantly higher.
Title: Expression of lysophosphatidic acid receptor 1 and relation with cell proliferation, apoptosis, and angiogenesis on preneoplastic changes induced by cadmium chloride in the rat ventral prostate.
These findings identified opposite subtype-specific functions for LPA1 and LPA3 in mediating cardiomyocyte hypertrophy and indicated LPA1 to be a target of miR-23a
Title: Reciprocal regulation of miR-23a and lysophosphatidic acid receptor signaling in cardiomyocyte hypertrophy.
These results suggest that activation of LPA signaling via mutated LPA(1) may play an important role in the promotion of angiogenesis in rat neuroblastoma cells.
Title: Enhancement of endothelial cell migration by constitutively active LPA(1)-expressing tumor cells.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

RH131839 (e-PCR)
- UniSTS:215122

UniSTS:143241 (e-PCR)
- UniSTS:143241

Edg2 (e-PCR), detects polymorphism
- UniSTS:143241

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables G-protein alpha-subunit binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid receptor activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in calmodulin dependent kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxygen levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in myelination	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in oligodendrocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle cycle	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysophosphatidic acid receptor 1

Names: LPA receptor 1; LPA-1; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lysophosphatidic acid receptor Edg-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053936.4 → NP_446388.1 lysophosphatidic acid receptor 1

See identical proteins and their annotated locations for NP_446388.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

78024139..78147071 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287075.1 → XP_063143145.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2
XM_006238195.5 → XP_006238257.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006238257.1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Related

ENSRNOP00000043652.2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017593125.3 → XP_017448614.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006238201.5 → XP_006238263.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006238263.1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006238197.5 → XP_006238259.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006238259.1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063287076.1 → XP_063143146.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2
XM_063287077.1 → XP_063143147.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2
XM_017593127.3 → XP_017448616.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063287078.1 → XP_063143148.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2
XM_006238200.5 → XP_006238262.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006238262.1

UniProtKB/Swiss-Prot

P61794, Q5FWS2

UniProtKB/TrEMBL

A6KDV2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017593130.3 → XP_017448619.1 lysophosphatidic acid receptor 1 isoform X2

Conserved Domains (1) summary

cd15344
Location:32 → 304

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors