Ppt1 palmitoyl-protein thioesterase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppt1provided by RGD
Official Full Name: palmitoyl-protein thioesterase 1provided by RGD
Primary source: RGD:61994
See related: Ensembl:ENSRNOG00000012616 AllianceGenome:RGD:61994
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppt
Summary: Predicted to enable lysophosphatidic acid binding activity; sulfatide binding activity; and thiolester hydrolase activity. Predicted to be involved in several processes, including lysosomal lumen acidification; positive regulation of endocytosis; and protein depalmitoylation. Predicted to act upstream of or within several processes, including grooming behavior; regulation of phospholipase A2 activity; and visual perception. Located in several cellular components, including lysosome; neuronal cell body; and synaptic vesicle. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 941.8), Lung (RPKM 709.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140406318..140427201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135121164..135142048)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140538260..140558163)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPT1 expression may provide a testicular marker of reduced fertility in obese males, as increases in its expression may be detrimental to Sertoli-cell function during spermatogenesis.
Title: Palmitoyl-protein thioesterase 1 (PPT1): an obesity-induced rat testicular marker of reduced fertility.
Palmitoyl-protein thioesterase 1 is progressively increased in pyramidal neurons of the hippocampus following epileptic seizures, may protect neurons from excitotoxicity, and may have a role in synaptic plasticity.
Title: Status epilepticus induces changes in the expression and localization of endogenous palmitoyl-protein thioesterase 1.

Submit: New GeneRIF Correction

General gene information

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Markers

Ppt (e-PCR), detects polymorphism
- UniSTS:518466

RH127550 (e-PCR)
- UniSTS:210860

AA851880 (e-PCR)
- UniSTS:261824

RH142418 (e-PCR)
- UniSTS:231665

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables palmitoyl hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-(protein) hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sulfatide binding	ISO Inferred from Sequence Orthology more info
enables sulfatide binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in lysosomal lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in lysosomal lumen acidification	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macromolecule catabolic process	ISO Inferred from Sequence Orthology more info
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macromolecule depalmitoylation	ISO Inferred from Sequence Orthology more info
involved_in membrane raft organization	ISO Inferred from Sequence Orthology more info
involved_in membrane raft organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pinocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: palmitoyl-protein thioesterase 1

Names: PPT-1; palmitoyl-protein hydrolase 1

NP_071947.1

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.