Commd5 COMM domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Commd5provided by RGD
Full Name: COMM domain containing 5provided by RGD
Primary source: RGD:621468
See related: Ensembl:ENSRNOG00000004484 AllianceGenome:RGD:621468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hcarg
Summary: Involved in several processes, including positive regulation of cell growth; positive regulation of epithelial cell differentiation; and proximal tubule morphogenesis. Located in nucleus. Orthologous to human COMMD5 (COMM domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 96.6), Kidney (RPKM 75.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (110502492..110503916)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (108621766..108623616)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117963213..117965010)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
Title: Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression.
data support a role for HCaRG in kidney repair after injury through its effect on renal cell migration and TGF-alpha secretion
Title: HCaRG increases renal cell migration by a TGF-alpha autocrine loop mechanism.
Hcarg localizes to the rat chromosome 7 between the markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and SHR rats.
Title: Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene.
HCaRG regulates renal epithelial cell growth and differentiation causing G(2)M cell cycle arrest
Title: HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing G2M arrest.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in proximal tubule morphogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: COMM domain-containing protein 5

Names: hypertension-related calcium-regulated gene protein; hypertension-related, calcium regulated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139108.2 → NP_620808.1 COMM domain-containing protein 5

See identical proteins and their annotated locations for NP_620808.1

Status: PROVISIONAL

Source sequence(s)

AF290194

UniProtKB/Swiss-Prot

Q9ERR2

UniProtKB/TrEMBL

A6HSE1, G3V6K0

Conserved Domains (1) summary

cd04753
Location:115 → 224

Commd5_HCaRG; COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal ...