Klhl31 kelch-like family member 31 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl31provided by RGD
Official Full Name: kelch-like family member 31provided by RGD
Primary source: RGD:1560540
See related: Ensembl:ENSRNOG00000006224 AllianceGenome:RGD:1560540
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560540
Summary: Predicted to be involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human KLHL31 (kelch like family member 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1246.2) and Heart (RPKM 604.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (87395878..87419236)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (78515514..78538873)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (84945444..84968811)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch-like protein 31

Names: kelch-like 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108170.2 → NP_001101640.1 kelch-like protein 31

See identical proteins and their annotated locations for NP_001101640.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I1G5, D3ZLT6

Related

ENSRNOP00000008243.2, ENSRNOT00000008244.4

Conserved Domains (4) summary

PHA03098
Location:73 → 601

PHA03098; kelch-like protein; Provisional

sd00038
Location:356 → 405

Kelch; KELCH repeat [structural motif]

cd18260
Location:55 → 174

BTB_POZ_KLHL31_KBTBD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31)

cl28903
Location:167 → 264

BACK; BACK (BTB and C-terminal Kelch) domain